5TEG
Crystal structure of hSETD8 in complex with histone H4K20 norleucine mutant peptide and S-Adenosylmethionine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | N-lysine methyltransferase KMT5A | polymer | 160 | 18213.5 | 2 | UniProt (Q9NQR1) Pfam (PF00856) | Homo sapiens (Human) | H4-K20-HMTase KMT5A,Histone-lysine N-methyltransferase KMT5A,Lysine N-methyltransferase 5A,Lysine-specific methylase 5A,PR/SET domain-containing protein 07,PR/SET07,SET domain-containing protein 8 |
| 2 | C, D (D, E) | Histone H4 mutant peptide with H4K20norleucine | polymer | 8 | 1082.4 | 2 | UniProt (by SIFTS) (P62805) | Homo sapiens | |
| 3 | E, F (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 4 | G, H, I, J (A, B, D, E) | water | water | 18.0 | 330 | Chemie (HOH) |
Sequence modifications
A, B: 193 - 352 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Ser 302 | Cys 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 38591.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 796.9 | |
| All* | Total formula weight | 39388.7 |
