5TEG
Crystal structure of hSETD8 in complex with histone H4K20 norleucine mutant peptide and S-Adenosylmethionine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | N-lysine methyltransferase KMT5A | polymer | 160 | 18213.5 | 2 | UniProt (Q9NQR1) Pfam (PF00856) | Homo sapiens (Human) | H4-K20-HMTase KMT5A,Histone-lysine N-methyltransferase KMT5A,Lysine N-methyltransferase 5A,Lysine-specific methylase 5A,PR/SET domain-containing protein 07,PR/SET07,SET domain-containing protein 8 |
| 2 | C, D (D, E) | Histone H4 mutant peptide with H4K20norleucine | polymer | 8 | 1082.4 | 2 | UniProt (by SIFTS) (P62805) | Homo sapiens | |
| 3 | E, F (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (145712080) PubChem (5136) PubChem (34755) PubChem (9865603) PubChem (12312798) | |||
| 4 | G, H, I, J (A, B, D, E) | water | water | 18.0 | 330 | Chemie (HOH) |
Sequence modifications
A, B: 193 - 352 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Ser 302 | Cys 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 38591.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 796.9 | |
| All* | Total formula weight | 39388.7 |
