5TDM

TEV Cleaved Human ATP Citrate Lyase Bound to 4R-Hydroxycitrate and ADP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ATP-citrate synthase	polymer	431	47836.6	1	UniProt (P53396) Pfam (PF16114) In PDB	Homo sapiens (Human)	ATP-CITRATE (PRO-S-)-LYASE,ACL,CITRATE CLEAVAGE ENZYME
2	B	ATP-citrate synthase	polymer	324	35421.6	1	UniProt (P53396) Pfam (PF02629) Pfam (PF00549) In PDB	Homo sapiens (Human)	ATP-CITRATE (PRO-S-)-LYASE,ACL,CITRATE CLEAVAGE ENZYME
3	A	3-C-carboxy-2-deoxy-L-threo-pentaric acid	non-polymer		208.1	1	Chemie (7A2)
4	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
5	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	A	ADENOSINE	non-polymer		267.2	1	Chemie (ADN)
7	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
8		water	water		18.0	187	Chemie (HOH)

Sequence modifications

A: 1 - 425 (UniProt: P53396)

PDB	External Database	Details
Glu 426	-	SEE REMARK 999
Asn 427	-	SEE REMARK 999
Leu 428	-	SEE REMARK 999
Tyr 429	-	SEE REMARK 999
Phe 430	-	SEE REMARK 999
Gln 431	-	SEE REMARK 999

B: 488 - 810 (UniProt: P53396)

PDB	External Database	Details
Ser 487	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83258.2
Non-Polymers*	Number of molecules	7
	Total formula weight	1135.4
All*	Total formula weight	84393.6

*Water molecules are not included.