5TDM
TEV Cleaved Human ATP Citrate Lyase Bound to 4R-Hydroxycitrate and ADP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue 7A2 A 901 |
| Chain | Residue |
| A | SER308 |
| A | GLY309 |
| A | ALA345 |
| A | ASN346 |
| A | PHE347 |
| A | THR348 |
| A | ARG379 |
| A | HOH1004 |
| B | GLY665 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue ADP A 902 |
| Chain | Residue |
| A | VAL56 |
| A | LYS58 |
| A | ARG65 |
| A | ARG66 |
| A | GLY67 |
| A | PRO109 |
| A | PHE110 |
| A | VAL111 |
| A | GLU118 |
| A | VAL140 |
| A | ASN203 |
| A | PRO204 |
| A | LEU215 |
| A | ASP216 |
| A | MG903 |
| A | HOH1008 |
| A | HOH1038 |
| A | HOH1070 |
| A | HOH1087 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 903 |
| Chain | Residue |
| A | ASN203 |
| A | ASP216 |
| A | ADP902 |
| A | HOH1038 |
| A | HOH1087 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 901 |
| Chain | Residue |
| A | HOH1004 |
| B | GLU599 |
| B | NEP760 |
| B | HOH1001 |
| B | HOH1009 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 902 |
| Chain | Residue |
| B | TRP502 |
| B | LYS554 |
| B | ASN555 |
| B | MET556 |
| B | GLU584 |
| B | GLY808 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residues ADN A 904 and GOL A 905 |
| Chain | Residue |
| A | ARG33 |
| A | THR35 |
| A | THR38 |
| A | ASP39 |
| A | ARG42 |
| A | LEU43 |
| A | HOH1025 |
Functional Information from PROSITE/UniProt
| site_id | PS00399 |
| Number of Residues | 17 |
| Details | SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GtcAtmfssevQFGHAG |
| Chain | Residue | Details |
| B | GLY746-GLY762 |
| site_id | PS01216 |
| Number of Residues | 30 |
| Details | SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGGMSnElnniisrttdGvyegVAIGGD |
| Chain | Residue | Details |
| B | SER661-ASP690 |
| site_id | PS01217 |
| Number of Residues | 25 |
| Details | SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GrIwtMvAGGGASvvysDtIcdl.GG |
| Chain | Residue | Details |
| A | GLY273-GLY297 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22102020","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20558738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22102020","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20558738","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q91V92","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"PubMed","id":"1371749","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"23932781","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"23932781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"27664236","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23932781","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
