5TCK

Second Bromodomain from Leishmania donovani LdBPK.091320 complexed with Bromosporine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Uncharacterized protein	polymer	157	17959.3	2	UniProt (E9BA17) Pfam (PF00439) UniProt (by SIFTS) (A0A3Q8I8I6)	Leishmania donovani (strain BPK282A1)
2	C, G (A, B)	Bromosporine	non-polymer		404.4	2	Chemie (BMF)
3	D, H (A, B)	BETA-MERCAPTOETHANOL	non-polymer		78.1	2	Chemie (BME)
4	E, I (A, B)	SULFUR OXIDE	non-polymer		48.1	2	Chemie (SX)
5	F, J (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	K, L (A, B)	water	water		18.0	171	Chemie (HOH)

Sequence modifications

A, B: 161 - 300 (UniProt: E9BA17)

PDB	External Database	Details
Met 144	-	initiating methionine
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
His 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
Ser 151	-	expression tag
Ser 152	-	expression tag
Gly 153	-	expression tag
Arg 154	-	expression tag
Glu 155	-	expression tag
Asn 156	-	expression tag
Leu 157	-	expression tag
Tyr 158	-	expression tag
Phe 159	-	expression tag
Gln 160	-	expression tag
Gly 161	Ala 161	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35918.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1185.4
All*	Total formula weight	37104.0

*Water molecules are not included.