5TCI
Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, G, E, C) | Tryptophan synthase alpha chain | polymer | 276 | 28579.4 | 4 | UniProt (P9WFY1) Pfam (PF00290) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 2 | B, D, F, H (B, H, F, D) | Tryptophan synthase beta chain | polymer | 410 | 43562.7 | 4 | UniProt (P9WFX9) Pfam (PF00291) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 3 | I, O, U, Y (A, G, E, C) | MALONATE ION | non-polymer | 102.0 | 4 | Chemie (MLI) PubChem (9084) | |||
| 4 | BA, CA, J, L, M... (D, A, B, G, H...) | FORMIC ACID | non-polymer | 46.0 | 13 | Chemie (FMT) PubChem (284) | |||
| 5 | AA, K, R, V (D, B, H, F) | (2R,3S,4R)-3-(2'-fluoro[1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile | non-polymer | 282.3 | 4 | Chemie (79V) PubChem (54650471) PubChem (54650472) PubChem (54650473) PubChem (54650474) PubChem (54650475) PubChem (54650477) PubChem (54650476) PubChem (76161237) PubChem (176457402) | |||
| 6 | DA, EA, FA, GA, HA... (A, B, G, H, E...) | water | water | 18.0 | 520 | Chemie (HOH) |
Sequence modifications
A, G, E, C: 1 - 270 (UniProt: P9WFY1)
| PDB | External Database | Details |
|---|---|---|
| His 271 | - | expression tag |
| His 272 | - | expression tag |
| His 273 | - | expression tag |
| His 274 | - | expression tag |
| His 275 | - | expression tag |
| His 276 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 288568.6 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 2135.8 | |
| All* | Total formula weight | 290704.4 |
