5TCI

Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, G, E, C)	Tryptophan synthase alpha chain	polymer	276	28579.4	4	UniProt (P9WFY1) Pfam (PF00290)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
2	B, D, F, H (B, H, F, D)	Tryptophan synthase beta chain	polymer	410	43562.7	4	UniProt (P9WFX9) Pfam (PF00291)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
3	I, O, U, Y (A, G, E, C)	MALONATE ION	non-polymer		102.0	4	Chemie (MLI)
4	BA, CA, J, L, M... (D, A, B, G, H...)	FORMIC ACID	non-polymer		46.0	13	Chemie (FMT)
5	AA, K, R, V (D, B, H, F)	(2R,3S,4R)-3-(2'-fluoro[1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile	non-polymer		282.3	4	Chemie (79V)
6	DA, EA, FA, GA, HA... (A, B, G, H, E...)	water	water		18.0	520	Chemie (HOH)

Sequence modifications

A, G, E, C: 1 - 270 (UniProt: P9WFY1)

PDB	External Database	Details
His 271	-	expression tag
His 272	-	expression tag
His 273	-	expression tag
His 274	-	expression tag
His 275	-	expression tag
His 276	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	288568.6
Non-Polymers*	Number of molecules	21
	Total formula weight	2135.8
All*	Total formula weight	290704.4

*Water molecules are not included.