5TCI
Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | tryptophan biosynthetic process |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006568 | biological_process | tryptophan metabolic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000162 | biological_process | tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006568 | biological_process | tryptophan metabolic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0000162 | biological_process | tryptophan biosynthetic process |
| C | 0004834 | molecular_function | tryptophan synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006568 | biological_process | tryptophan metabolic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0000162 | biological_process | tryptophan biosynthetic process |
| D | 0004834 | molecular_function | tryptophan synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006568 | biological_process | tryptophan metabolic process |
| D | 0016829 | molecular_function | lyase activity |
| E | 0000162 | biological_process | tryptophan biosynthetic process |
| E | 0004834 | molecular_function | tryptophan synthase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006568 | biological_process | tryptophan metabolic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0000162 | biological_process | tryptophan biosynthetic process |
| F | 0004834 | molecular_function | tryptophan synthase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006568 | biological_process | tryptophan metabolic process |
| F | 0016829 | molecular_function | lyase activity |
| G | 0000162 | biological_process | tryptophan biosynthetic process |
| G | 0004834 | molecular_function | tryptophan synthase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006568 | biological_process | tryptophan metabolic process |
| G | 0016829 | molecular_function | lyase activity |
| H | 0000162 | biological_process | tryptophan biosynthetic process |
| H | 0004834 | molecular_function | tryptophan synthase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006568 | biological_process | tryptophan metabolic process |
| H | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue MLI A 301 |
| Chain | Residue |
| A | TYR181 |
| A | GLY217 |
| A | LEU218 |
| A | GLY219 |
| A | GLY239 |
| A | SER240 |
| A | HOH410 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 302 |
| Chain | Residue |
| A | TYR181 |
| A | ILE237 |
| A | GLU57 |
| A | MET106 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue 79V B 501 |
| Chain | Residue |
| A | ASP64 |
| A | GLY66 |
| A | TYR108 |
| A | ASP136 |
| A | HOH409 |
| B | PRO31 |
| B | TRP191 |
| B | TYR200 |
| B | PHE202 |
| B | PRO208 |
| B | PHE211 |
| B | HIS294 |
| B | GLY295 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 502 |
| Chain | Residue |
| B | LYS47 |
| B | GLU48 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 503 |
| Chain | Residue |
| B | ARG265 |
| B | ASP337 |
| B | ARG339 |
| B | GLU378 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 504 |
| Chain | Residue |
| B | LYS402 |
| B | GLY405 |
| B | HOH682 |
| H | TRP403 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue MLI G 301 |
| Chain | Residue |
| G | TYR181 |
| G | GLY217 |
| G | LEU218 |
| G | GLY219 |
| G | GLY239 |
| G | SER240 |
| G | HOH416 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue FMT G 302 |
| Chain | Residue |
| G | GLU57 |
| G | MET106 |
| G | TYR181 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue FMT G 303 |
| Chain | Residue |
| G | GLN144 |
| H | SER23 |
| site_id | AD1 |
| Number of Residues | 16 |
| Details | binding site for residue 79V H 501 |
| Chain | Residue |
| G | ASP64 |
| G | GLY66 |
| G | TYR108 |
| G | ASP136 |
| H | VAL30 |
| H | PRO31 |
| H | LEU34 |
| H | PHE188 |
| H | TRP191 |
| H | TYR200 |
| H | PHE202 |
| H | GLY207 |
| H | PRO208 |
| H | PHE211 |
| H | HIS294 |
| H | GLY295 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 502 |
| Chain | Residue |
| H | ARG265 |
| H | ASP337 |
| H | GLU378 |
| H | HOH627 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 503 |
| Chain | Residue |
| H | LYS47 |
| H | GLU48 |
| H | ARG114 |
| H | HOH637 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue MLI E 301 |
| Chain | Residue |
| E | TYR181 |
| E | GLY217 |
| E | GLY219 |
| E | GLY239 |
| E | SER240 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue 79V F 501 |
| Chain | Residue |
| E | ASP64 |
| E | GLY66 |
| E | MET67 |
| F | PRO31 |
| F | LEU34 |
| F | PHE188 |
| F | PHE202 |
| F | PRO208 |
| F | HIS294 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue FMT F 503 |
| Chain | Residue |
| F | GLU48 |
| F | ARG114 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue MLI C 301 |
| Chain | Residue |
| C | TYR181 |
| C | THR185 |
| C | GLY217 |
| C | GLY219 |
| C | GLY239 |
| C | SER240 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue FMT C 302 |
| Chain | Residue |
| C | GLU57 |
| C | TYR181 |
| C | ILE237 |
| site_id | AD9 |
| Number of Residues | 11 |
| Details | binding site for residue 79V D 501 |
| Chain | Residue |
| D | PRO31 |
| D | LEU34 |
| D | ASN185 |
| D | PHE188 |
| D | PHE202 |
| D | PRO208 |
| D | HIS294 |
| C | ASP64 |
| C | GLY66 |
| C | MET67 |
| C | ASP136 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 502 |
| Chain | Residue |
| D | LYS47 |
| D | GLU48 |
| D | ARG114 |
| site_id | AE2 |
| Number of Residues | 1 |
| Details | binding site for residue FMT D 503 |
| Chain | Residue |
| D | LEU259 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGvPYSDPGMDG |
| Chain | Residue | Details |
| A | ILE56-GLY69 |
| site_id | PS00168 |
| Number of Residues | 15 |
| Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LnHtGSHKiNnvLgQ |
| Chain | Residue | Details |
| B | LEU94-GLN108 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_00133 |
| Chain | Residue | Details |
| B | HIS100 | |
| H | HIS100 | |
| F | HIS100 | |
| D | HIS100 | |
| E | GLU57 | |
| E | ASP68 | |
| C | GLU57 | |
| C | ASP68 |
