5TBP
Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Retinoic acid receptor RXR-alpha | polymer | 244 | 27269.5 | 4 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | E, F, G, M, R... (A, B, D) | [(1Z)-5-fluoro-2-methyl-1-{[4-(propan-2-yl)phenyl]methylidene}-1H-inden-3-yl]acetic acid | non-polymer | 336.4 | 6 | Chemie (7A4) | |||
| 3 | H, I, K, L, O... (A, B, D) | ACETATE ION | non-polymer | 59.0 | 7 | Chemie (ACT) | |||
| 4 | J (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | N, Q (B, C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 223 - 462 (UniProt: P19793)
| PDB | External Database | Details |
|---|---|---|
| Gly 219 | - | expression tag |
| Ser 220 | - | expression tag |
| His 221 | - | expression tag |
| Met 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 109078.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2694.0 | |
| All* | Total formula weight | 111772.1 |
