5TBP
Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003707 | molecular_function | nuclear steroid receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003707 | molecular_function | nuclear steroid receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue 7A4 A 501 |
| Chain | Residue |
| A | ALA272 |
| A | GLN275 |
| A | LEU276 |
| A | LEU301 |
| A | ARG302 |
| A | TRP305 |
| C | PHE439 |
| C | LYS440 |
| C | LEU451 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue 7A4 A 502 |
| Chain | Residue |
| A | ILE268 |
| A | ALA271 |
| A | ALA272 |
| A | GLN275 |
| A | LEU309 |
| A | PHE313 |
| A | ARG316 |
| A | ALA327 |
| A | THR328 |
| A | PHE438 |
| A | ILE442 |
| C | GOL501 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue 7A4 A 503 |
| Chain | Residue |
| A | VAL265 |
| A | LEU436 |
| A | PHE439 |
| A | ILE447 |
| C | ASP273 |
| C | LEU276 |
| C | ARG302 |
| C | TRP305 |
| C | GOL501 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue ACT A 504 |
| Chain | Residue |
| A | ARG285 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue ACT A 505 |
| Chain | Residue |
| A | HIS288 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue DMS A 506 |
| Chain | Residue |
| A | PRO287 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 507 |
| Chain | Residue |
| A | PRO378 |
| A | GLU390 |
| A | ARG393 |
| A | HOH602 |
| B | LEU420 |
| B | ARG421 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 508 |
| Chain | Residue |
| A | LYS440 |
| A | LEU441 |
| A | ILE442 |
| A | ASP444 |
| A | THR445 |
| A | PRO446 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue 7A4 B 501 |
| Chain | Residue |
| B | ASP273 |
| B | LEU276 |
| B | ARG302 |
| B | TRP305 |
| B | GOL502 |
| D | VAL265 |
| D | LEU436 |
| D | PHE439 |
| D | ILE447 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | PHE439 |
| B | 7A4501 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 503 |
| Chain | Residue |
| B | ARG234 |
| B | ARG285 |
| D | GLN460 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue ACT B 504 |
| Chain | Residue |
| B | GLN275 |
| B | LEU309 |
| B | PHE313 |
| B | ARG316 |
| B | LEU326 |
| B | ALA327 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| A | 7A4502 |
| A | 7A4503 |
| C | PHE439 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue 7A4 D 501 |
| Chain | Residue |
| B | PHE439 |
| B | LYS440 |
| B | LEU451 |
| D | ALA272 |
| D | LEU276 |
| D | LEU301 |
| D | ARG302 |
| D | TRP305 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue 7A4 D 502 |
| Chain | Residue |
| D | ALA271 |
| D | ALA272 |
| D | GLN275 |
| D | LEU309 |
| D | ARG316 |
| D | ALA327 |
| D | PHE438 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue ACT D 503 |
| Chain | Residue |
| D | ASP359 |
| D | MET360 |
| D | GLN361 |
| D | GLN411 |
| D | ARG414 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
