5T7O
Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 521 | 58928.1 | 4 | UniProt (Q4DLS1) Pfam (PF00186) Pfam (PF00303) In PDB | Trypanosoma cruzi (strain CL Brener) | |
| 2 | A, C, B, D | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 3 | D, A, C, B | (6S)-5,6,7,8-TETRAHYDROFOLATE | non-polymer | 445.4 | 4 | Chemie (THG) | |||
| 4 | A, C, B, D | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 4 | Chemie (UMP) | |||
| 5 | B, D, A, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 47 | Chemie (EDO) | |||
| 6 | water | water | 18.0 | 2024 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 235712.5 | |
| Non-Polymers* | Number of molecules | 59 |
| Total formula weight | 8905.3 | |
| All* | Total formula weight | 244617.7 |
