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5T7O

Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Bifunctional dihydrofolate reductase-thymidylate synthasepolymer52158928.14UniProt (Q4DLS1)
Pfam (PF00186)
Pfam (PF00303)
Trypanosoma cruzi (strain CL Brener)
2E, LA, X, YA
(A, C, B, D)
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer743.44Chemie (NAP)
3AB, F, KA, V
(D, A, C, B)
(6S)-5,6,7,8-TETRAHYDROFOLATEnon-polymer445.44Chemie (THG)
4G, MA, W, ZA
(A, C, B, D)
2'-DEOXYURIDINE 5'-MONOPHOSPHATEnon-polymer308.24Chemie (UMP)
5AA, BA, BB, CA, CB...
(B, D, A, C)
1,2-ETHANEDIOLnon-polymer62.147Chemie (EDO)
6LB, MB, NB, OB
(A, B, C, D)
waterwater18.02024Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight235712.5
Non-Polymers*Number of molecules59
Total formula weight8905.3
All*Total formula weight244617.7
*Water molecules are not included.

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PDB entries from 2024-11-06

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