5SXH

Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	DNA dC->dU-editing enzyme APOBEC-3B	polymer	185	21821.7	2	UniProt (Q9UH17)	Homo sapiens (human)	A3B,Phorbolin-1-related protein,Phorbolin-2/3
2	C, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, E, G (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
4	H, I (A, B)	water	water		18.0	207	Chemie (HOH)

Sequence modifications

A, B: 191 - 378 (UniProt: Q9UH17)

PDB	External Database	Details
Ser 186	-	expression tag
Glu 187	-	expression tag
Ile 188	-	expression tag
Leu 189	-	expression tag
Arg 190	-	expression tag
Ser 200	Phe 200	engineered mutation
Ser 228	Trp 228	engineered mutation
Lys 230	Leu 230	engineered mutation
-	Ala 242	deletion
-	Lys 243	deletion
-	Asn 244	deletion
-	Leu 245	deletion
-	Leu 246	deletion
-	Cys 247	deletion
-	Gly 248	deletion
-	Phe 249	deletion
Ser 250	Tyr 250	engineered mutation
Lys 308	Phe 308	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43643.4
Non-Polymers*	Number of molecules	5
	Total formula weight	317.0
All*	Total formula weight	43960.4

*Water molecules are not included.