5SXH
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | DNA dC->dU-editing enzyme APOBEC-3B | polymer | 185 | 21821.7 | 2 | UniProt (Q9UH17) Pfam (PF05240) In PDB | Homo sapiens (human) | A3B,Phorbolin-1-related protein,Phorbolin-2/3 |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
4 | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A, B: 191 - 378 (UniProt: Q9UH17)
PDB | External Database | Details |
---|---|---|
Ser 186 | - | expression tag |
Glu 187 | - | expression tag |
Ile 188 | - | expression tag |
Leu 189 | - | expression tag |
Arg 190 | - | expression tag |
Ser 200 | Phe 200 | engineered mutation |
Ser 228 | Trp 228 | engineered mutation |
Lys 230 | Leu 230 | engineered mutation |
- | Ala 242 | deletion |
- | Lys 243 | deletion |
- | Asn 244 | deletion |
- | Leu 245 | deletion |
- | Leu 246 | deletion |
- | Cys 247 | deletion |
- | Gly 248 | deletion |
- | Phe 249 | deletion |
Ser 250 | Tyr 250 | engineered mutation |
Lys 308 | Phe 308 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 43643.4 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 317.0 | |
All* | Total formula weight | 43960.4 |