5SVN
Structure of IDH2 mutant R172K
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Isocitrate dehydrogenase [NADP], mitochondrial | polymer | 424 | 48087.8 | 2 | UniProt (P48735) Pfam (PF00180) In PDB | Homo sapiens (Human) | IDH,ICD-M,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase |
2 | A, B | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
3 | A, B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
4 | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A, B: 40 - 452 (UniProt: P48735)
PDB | External Database | Details |
---|---|---|
Lys 172 | Arg 172 | engineered mutation |
Ser 453 | - | expression tag |
Leu 454 | - | expression tag |
Glu 455 | - | expression tag |
His 456 | - | expression tag |
His 457 | - | expression tag |
His 458 | - | expression tag |
His 459 | - | expression tag |
His 460 | - | expression tag |
His 461 | - | expression tag |
His 462 | - | expression tag |
His 463 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 96175.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1703.1 | |
All* | Total formula weight | 97878.7 |