5SVN

Structure of IDH2 mutant R172K

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isocitrate dehydrogenase [NADP], mitochondrial	polymer	424	48087.8	2	UniProt (P48735) Pfam (PF00180)	Homo sapiens (Human)	IDH,ICD-M,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase
2	C, E (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
3	D, F (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
4	G, H (A, B)	water	water		18.0	207	Chemie (HOH)

Sequence modifications

A, B: 40 - 452 (UniProt: P48735)

PDB	External Database	Details
Lys 172	Arg 172	engineered mutation
Ser 453	-	expression tag
Leu 454	-	expression tag
Glu 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag
His 461	-	expression tag
His 462	-	expression tag
His 463	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	96175.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1703.1
All*	Total formula weight	97878.7

*Water molecules are not included.