5SVK
Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | P2X purinoceptor 3 | polymer | 363 | 40745.9 | 2 | UniProt (P56373) Pfam (PF00864) | Homo sapiens (Human) | P2X3,ATP receptor,Purinergic receptor |
| 2 | C, D, E, F (C, D, E, F) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 4 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
| 3 | G, N (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 4 | H, I, J, K, O... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 5 | L, R (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | M (A) | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID | non-polymer | 190.2 | 1 | Chemie (MHA) | |||
| 7 | S, T (A, B) | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
A, B: 6 - 364 (UniProt: P56373)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Arg 4 | - | expression tag |
| Ala 5 | - | expression tag |
| Pro 13 | Thr 13 | engineered mutation |
| Val 15 | Ser 15 | engineered mutation |
| Ile 16 | Val 16 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 81491.8 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1369.2 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2877.1 | |
| All* | Total formula weight | 85738.1 |
