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5SIO

Crystal Structure of human phosphodiesterase 10 in complex with 2-methyl-4-(2-methylpyrrolidine-1-carbonyl)-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)pyrazole-3-carboxamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer34339413.24UniProt (Q9Y233)
In PDB
Homo sapiens (human)
2A, B, C, DZINC IONnon-polymer65.44Chemie (ZN)
3A, B, C, DMAGNESIUM IONnon-polymer24.34Chemie (MG)
4ACHLORIDE IONnon-polymer35.51Chemie (CL)
5A, B, C, D1-methyl-4-[(2R)-2-methylpyrrolidine-1-carbonyl]-N-[(4R)-2-phenylimidazo[1,2-a]pyridin-7-yl]-1H-pyrazole-5-carboxamidenon-polymer428.54Chemie (JRC)
6B, CPRASEODYMIUM IONnon-polymer140.95Chemie (PR)
7waterwater18.0417Chemie (HOH)
Sequence modifications
A, B, C, D: 449 - 789 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 447-expression tag
Ser 448-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight157652.8
Non-Polymers*Number of molecules18
Total formula weight2812.8
All*Total formula weight160465.6
*Water molecules are not included.

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PDB entries from 2024-06-12

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