Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5SHR

Crystal Structure of human phosphodiesterase 10 in complex with N-[(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methyl]-N,2-dimethyl-5-phenyl-1,2,4-triazol-3-amine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer34339489.31UniProt (Q9Y233)
In PDB
Homo sapiens (human)
2B, C, DcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer34339413.23UniProt (Q9Y233)
In PDB
Homo sapiens (Human)
3A, B, C, DZINC IONnon-polymer65.44Chemie (ZN)
4A, B, C, DMAGNESIUM IONnon-polymer24.34Chemie (MG)
5A, B, C, DN-{[(4R)-5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl]methyl}-N,1-dimethyl-3-phenyl-1H-1,2,4-triazol-5-aminenon-polymer348.44Chemie (JIP)
6waterwater18.0499Chemie (HOH)
Sequence modifications
A: 449 - 789 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 447-expression tag
Ser 448-expression tag
B, C, D: 449 - 789 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 447-expression tag
Ser 448-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight157728.9
Non-Polymers*Number of molecules12
Total formula weight1752.5
All*Total formula weight159481.4
*Water molecules are not included.

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon