5S9Q
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH 2-(3,5-dimethyl-1,2-oxazol-4-yl)-7-(2-hydroxypropan-2-yl)-9-[(S)-(oxan-4-yl)(phenyl)methyl]-9H-carbazole-4-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, D, E) | Bromodomain-containing protein 4 | polymer | 128 | 15207.5 | 4 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | E, G, H, K (A, B, D, E) | 2-(3,5-dimethyl-1,2-oxazol-4-yl)-7-(2-hydroxypropan-2-yl)-9-[(S)-(oxan-4-yl)(phenyl)methyl]-9H-carbazole-4-carboxamide | non-polymer | 537.6 | 4 | Chemie (YW7) | |||
| 3 | F, I, J, L (A, D, E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | M, N, O, P (A, B, D, E) | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gly 41 | - | expression tag |
| His 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60830.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2398.9 | |
| All* | Total formula weight | 63228.9 |
