5QJ1
CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | RNA-dependent RNA polymerase | polymer | 574 | 63931.4 | 1 | UniProt (R9THT8) Pfam (PF00998) UniProt (by SIFTS) (Q99IB8) In PDB | Hepacivirus C | |
| 2 | A | 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide | non-polymer | 597.6 | 1 | Chemie (J6J) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 3 | Chemie (PG4) | |||
| 6 | water | water | 18.0 | 322 | Chemie (HOH) |
Sequence modifications
A: 1 - 573 (UniProt: R9THT8)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 30 | Leu 2472 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 63931.4 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2513.3 | |
| All* | Total formula weight | 66444.7 |
