5QJ1

CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue J6J A 601

Chain	Residue
A	PHE193
A	ILE363
A	SER365
A	CYS366
A	SER368
A	LEU384
A	GLN414
A	TYR415
A	TYR448
A	LEU466
A	HOH706
A	GLN194
A	TYR195
A	SER196
A	ARG200
A	LEU204
A	LEU314
A	CYS316
A	VAL321

---

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 A 602

Chain	Residue
A	ASN24
A	ASN24
A	SER27
A	SER27
A	SER30
A	SER30
A	HOH736
A	HOH736

---

site_id	AC3
Number of Residues	10
Details	binding site for residue SO4 A 603

Chain	Residue
A	ARG422
A	SER473
A	MET474
A	HIS475
A	ASN527
A	TRP528
A	LYS533
A	HOH746
A	HOH752
A	HOH841

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 604

Chain	Residue
A	ARG505
A	VAL530
A	LYS531
A	THR532

---

site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 A 605

Chain	Residue
A	PRO93
A	SER96
A	ARG168
A	LYS172
A	HOH793
A	HOH856
A	HOH887

---

site_id	AC6
Number of Residues	8
Details	binding site for residue SO4 A 606

Chain	Residue
A	LYS77
A	THR273
A	HOH730
A	HOH734
A	HOH786
A	HOH804
A	HOH875
A	HOH914

---

site_id	AC7
Number of Residues	8
Details	binding site for residue SO4 A 607

Chain	Residue
A	GLY375
A	PRO376
A	ARG377
A	GLY378
A	ARG379
A	ARG381
A	HOH781
A	HOH912

---

site_id	AC8
Number of Residues	7
Details	binding site for residue SO4 A 608

Chain	Residue
A	GLU361
A	SER371
A	VAL372
A	SER478
A	HOH743
A	HOH776
A	HOH791

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 A 609

Chain	Residue
A	PRO94
A	GLY104
A	ALA105
A	LYS106
A	HOH768

---

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 A 610

Chain	Residue
A	GLY188
A	ALA189

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 A 611

Chain	Residue
A	ARG508
A	ILE512
A	ARG523
A	LEU534

---

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 A 612

Chain	Residue
A	PRO496
A	LEU497
A	ARG498
A	HOH885

---

site_id	AD4
Number of Residues	8
Details	binding site for residue GOL A 613

Chain	Residue
A	TYR4
A	ARG48
A	VAL52
A	ARG158
A	LEU159
A	ASP225
A	SER226
A	HOH712

---

site_id	AD5
Number of Residues	4
Details	binding site for residue GOL A 614

Chain	Residue
A	LYS50
A	PRO246
A	GLU247
A	GLU248

---

site_id	AD6
Number of Residues	4
Details	binding site for residue GOL A 615

Chain	Residue
A	GLY468
A	LEU469
A	HOH895
A	GLU464

---

site_id	AD7
Number of Residues	6
Details	binding site for residue PG4 A 616

Chain	Residue
A	LYS100
A	THR137
A	ASN268
A	SER269
A	GLY271
A	HOH880

---

site_id	AD8
Number of Residues	7
Details	binding site for residue PG4 A 617

Chain	Residue
A	PHE145
A	CYS146
A	SER367
A	ARG386
A	THR390
A	ARG394
A	HOH833

---

site_id	AD9
Number of Residues	5
Details	binding site for residue PG4 A 618

Chain	Residue
A	HIS118
A	SER121
A	THR329
A	GLU333
A	HOH790

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P26663","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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