5QC9
Crystal structure of human Cathepsin-S with bound ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Cathepsin S | polymer | 223 | 24516.5 | 2 | UniProt (P25774) Pfam (PF00112) In PDB | Homo sapiens (Human) | |
2 | A, B | N-{[5-{1-[3-(dimethylamino)propyl]-5-[(piperidin-4-yl)acetyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}-2-(trifluoromethyl)phenyl]methyl}-3-methylbut-2-enamide | non-polymer | 588.7 | 2 | Chemie (BG7) | |||
3 | water | water | 18.0 | 576 | Chemie (HOH) |
Sequence modifications
A, B: 0 - 217 (UniProt: P25774)
PDB | External Database | Details |
---|---|---|
Ser 25 | Cys 139 | engineered mutation |
Leu 218 | - | expression tag |
Gln 219 | - | expression tag |
Gly 220 | - | expression tag |
Gly 221 | - | expression tag |
Gly 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 49032.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1177.4 | |
All* | Total formula weight | 50210.4 |