5OSA

GLIC-GABAAR alpha1 chimera crystallized at pH4.6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E (A, B, C, D, E)	Proton-gated ion channel,Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1	polymer	336	38644.2	5	UniProt (Q7NDN8) UniProt (P62812) Pfam (PF02931) Pfam (PF02932)	Gloeobacter violaceus (strain PCC 7421)	GLIC,Ligand-gated ion channel,LGIC,GABA(A) receptor subunit alpha-1,GABA(A) receptor subunit alpha-1
2	CA, F, G, M, R... (E, A, B, C, D)	ACETATE ION	non-polymer		59.0	8	Chemie (ACT)
3	DA, H, I, J, N... (E, A, B, C, D)	CHLORIDE ION	non-polymer		35.5	7	Chemie (CL)
4	AA, EA, FA, K, O... (D, E, A, B, C)	DODECANE	non-polymer		170.3	8	Chemie (D12)
5	BA, GA, L, Q, V (D, E, A, B, C)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	5	Chemie (Y01)
6	HA, IA, JA, KA, LA (A, B, C, D, E)	water	water		18.0	35	Chemie (HOH)

Sequence modifications

A, B, C, D, E: 1 - 193 (UniProt: Q7NDN8)
A, B, C, D, E: 223 - 311 (UniProt: P62812)

PDB	External Database	Details
Val 258	Gly 285	conflict

A, B, C, D, E: 390 - 428 (UniProt: P62812)

PDB	External Database	Details
Ser 312	-	linker
Gln 313	-	linker
Pro 314	-	linker
Ala 315	-	linker
Arg 316	-	linker
Ala 317	-	linker
Ala 318	-	linker
His 429	-	expression tag
His 430	-	expression tag
His 431	-	expression tag
His 432	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	193220.9
Non-Polymers*	Number of molecules	28
	Total formula weight	4516.8
All*	Total formula weight	197737.7

*Water molecules are not included.