Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5OSA

GLIC-GABAAR alpha1 chimera crystallized at pH4.6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ACT A 501

Chain	Residue
A	ARG76
A	ILE130
A	GLU180
E	ILE24
E	PHE41
E	ARG104

site_id	AC2
Number of Residues	4
Details	binding site for residue ACT A 502

Chain	Residue
A	ARG84
A	ILE72
A	PRO73
A	ILE75

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 503

Chain	Residue
A	PHE77
A	ARG84

site_id	AC4
Number of Residues	1
Details	binding site for residue CL A 504

Chain	Residue
D	HOH608

site_id	AC5
Number of Residues	1
Details	binding site for residue D12 A 506

Chain	Residue
A	LEU394

site_id	AC6
Number of Residues	3
Details	binding site for residue Y01 A 507

Chain	Residue
A	SER269
A	ALA294
E	ILE227

site_id	AC7
Number of Residues	5
Details	binding site for residue ACT B 501

Chain	Residue
A	PHE41
A	ARG104
B	ARG76
B	ILE130
B	GLU180

site_id	AC8
Number of Residues	2
Details	binding site for residue CL B 502

Chain	Residue
B	PHE77
B	ARG84

site_id	AC9
Number of Residues	3
Details	binding site for residue Y01 B 505

Chain	Residue
B	SER269
B	ALA290
B	PHE297

site_id	AD1
Number of Residues	5
Details	binding site for residue ACT C 501

Chain	Residue
B	PHE41
B	ARG104
C	ARG76
C	ILE130
C	GLU180

site_id	AD2
Number of Residues	3
Details	binding site for residue ACT C 502

Chain	Residue
C	PRO73
C	ILE75
C	ARG84

site_id	AD3
Number of Residues	2
Details	binding site for residue CL C 503

Chain	Residue
C	PHE77
C	ARG84

site_id	AD4
Number of Residues	5
Details	binding site for residue Y01 C 505

Chain	Residue
B	LEU231
C	SER269
C	ASP286
C	ALA290
C	ALA294

site_id	AD5
Number of Residues	5
Details	binding site for residue ACT D 501

Chain	Residue
C	PHE41
C	ARG104
D	ARG76
D	ILE130
D	GLU180

site_id	AD6
Number of Residues	3
Details	binding site for residue ACT D 502

Chain	Residue
D	PRO73
D	ILE75
D	ARG84

site_id	AD7
Number of Residues	2
Details	binding site for residue CL D 503

Chain	Residue
D	PHE77
D	ARG84

site_id	AD8
Number of Residues	2
Details	binding site for residue D12 D 505

Chain	Residue
D	ASN407
D	TRP411

site_id	AD9
Number of Residues	4
Details	binding site for residue Y01 D 506

Chain	Residue
D	SER269
D	ASP286
D	TYR293
D	ALA294

site_id	AE1
Number of Residues	5
Details	binding site for residue ACT E 501

Chain	Residue
D	PHE41
D	ARG104
E	ARG76
E	ILE130
E	GLU180

site_id	AE2
Number of Residues	2
Details	binding site for residue CL E 502

Chain	Residue
E	PHE77
E	ARG84

site_id	AE3
Number of Residues	3
Details	binding site for residue D12 E 504

Chain	Residue
E	TYR193
E	TRP411
E	LEU415

site_id	AE4
Number of Residues	5
Details	binding site for residue Y01 E 505

Chain	Residue
D	ILE227
D	MET235
E	SER269
E	ASP286
E	ALA294

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	955
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN1-GLN192
B	GLN1-GLN192
C	GLN1-GLN192
D	GLN1-GLN192
E	GLN1-GLN192

site_id	SWS_FT_FI2
Number of Residues	405
Details	TRANSMEM: Helical => ECO:0000250\|UniProtKB:P14867

Chain	Residue	Details
A	VAL226-LEU246
C	PRO252-ARG273
C	ALA284-THR305
C	LEU394-THR413
D	VAL226-LEU246
D	PRO252-ARG273
D	ALA284-THR305
D	LEU394-THR413
E	VAL226-LEU246
E	PRO252-ARG273
E	ALA284-THR305
A	PRO252-ARG273
E	LEU394-THR413
A	ALA284-THR305
A	LEU394-THR413
B	VAL226-LEU246
B	PRO252-ARG273
B	ALA284-THR305
B	LEU394-THR413
C	VAL226-LEU246

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	ASN247-VAL251
B	ASN247-VAL251
C	ASN247-VAL251
D	ASN247-VAL251
E	ASN247-VAL251

site_id	SWS_FT_FI4
Number of Residues	115
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ASN274-THR283
E	TYR414-GLN428
A	TYR414-GLN428
B	ASN274-THR283
B	TYR414-GLN428
C	ASN274-THR283
C	TYR414-GLN428
D	ASN274-THR283
D	TYR414-GLN428
E	ASN274-THR283

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)