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5OCU

Molecular basis of human kinesin-8 function and inhibition

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(K)
Kinesin-like protein KIF18Apolymer37742213.91UniProt (Q8NI77)
Pfam (PF00225)
Homo sapiens (Human)Marrow stromal KIF18A,MS-KIF18A
2B
(A)
Tubulin alpha chainpolymer45150107.21UniProt (F2Z4C1)
Pfam (PF00091)
Pfam (PF03953)
UniProt (by SIFTS) (P81947)
Bos taurus (Bovine)
3C
(B)
Tubulin beta chainpolymer44549907.81UniProt (P02554)
Pfam (PF00091)
Pfam (PF03953)
Sus scrofa (Pig)Beta-tubulin
4D, G
(K, A)
MAGNESIUM IONnon-polymer24.32Chemie (MG)
5E
(K)
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.21Chemie (ANP)
6F
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
7H
(A)
GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
8I
(B)
GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
9J
(B)
TAXOLnon-polymer853.91Chemie (TA1)
Sequence modifications
K: 1 - 374 (UniProt: Q8NI77)
PDBExternal DatabaseDetails
Gly -2-expression tag
Ser -1-expression tag
His 0-expression tag
A: 1 - 451 (UniProt: F2Z4C1)
PDBExternal DatabaseDetails
Ser 136Leu 136conflict
Gly 265Ile 265conflict
Glu 358Gln 358conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight142228.9
Non-Polymers*Number of molecules7
Total formula weight2440.5
All*Total formula weight144669.4
*Water molecules are not included.

226707

PDB entries from 2024-10-30

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