5OCU
Molecular basis of human kinesin-8 function and inhibition
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (K) | Kinesin-like protein KIF18A | polymer | 377 | 42213.9 | 1 | UniProt (Q8NI77) Pfam (PF00225) | Homo sapiens (Human) | Marrow stromal KIF18A,MS-KIF18A |
| 2 | B (A) | Tubulin alpha chain | polymer | 451 | 50107.2 | 1 | UniProt (F2Z4C1) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (P81947) | Bos taurus (Bovine) | |
| 3 | C (B) | Tubulin beta chain | polymer | 445 | 49907.8 | 1 | UniProt (P02554) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (Pig) | Beta-tubulin |
| 4 | D, G (K, A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | E (K) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 6 | F (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | H (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 8 | I (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 9 | J (B) | TAXOL | non-polymer | 853.9 | 1 | Chemie (TA1) |
Sequence modifications
K: 1 - 374 (UniProt: Q8NI77)
A: 1 - 451 (UniProt: F2Z4C1)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 136 | Leu 136 | conflict |
| Gly 265 | Ile 265 | conflict |
| Glu 358 | Gln 358 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 142228.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2440.5 | |
| All* | Total formula weight | 144669.4 |
