5OAJ
Crystal structure of mutant AChBP in complex with tropisetron (T53F, Q74R, Y110A, I135S, G162E)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Soluble acetylcholine receptor | polymer | 249 | 28355.8 | 10 | UniProt (Q8WSF8) Pfam (PF02931) In PDB | Aplysia californica (California sea hare) | |
2 | E, A, H, I | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
3 | D, I, E, J, F... | 1,2-ETHANEDIOL | non-polymer | 62.1 | 42 | Chemie (EDO) | |||
4 | G, C, I | CITRATE ANION | non-polymer | 189.1 | 3 | Chemie (FLC) | |||
5 | E, J | (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE | non-polymer | 284.4 | 2 | Chemie (TKT) | |||
6 | water | water | 18.0 | 541 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J: 1 - 236 (UniProt: Q8WSF8)
PDB | External Database | Details |
---|---|---|
Phe 53 | Thr 53 | engineered mutation |
Val 60 | Ala 60 | conflict |
Arg 74 | Gln 74 | engineered mutation |
Ala 110 | Tyr 110 | engineered mutation |
Ser 135 | Ile 135 | engineered mutation |
Val 155 | Ala 155 | conflict |
Glu 162 | Gly 162 | engineered mutation |
Glu 237 | - | expression tag |
Asn 238 | - | expression tag |
Leu 239 | - | expression tag |
Tyr 240 | - | expression tag |
Phe 241 | - | expression tag |
Gln 242 | - | expression tag |
Gly 243 | - | expression tag |
His 244 | - | expression tag |
His 245 | - | expression tag |
His 246 | - | expression tag |
His 247 | - | expression tag |
His 248 | - | expression tag |
His 249 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 283557.7 | |
Non-Polymers* | Number of molecules | 51 |
Total formula weight | 4627.7 | |
All* | Total formula weight | 288185.4 |