5O9A
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504Y-N775S) in complex with glutamate and BPAM121 at 1.78 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Glutamate receptor 2,Glutamate receptor 2 | polymer | 264 | 29301.7 | 4 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Norway Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | C, A, D, B | SULFATE ION | non-polymer | 96.1 | 16 | Chemie (SO4) | |||
| 3 | C, A, D, B | 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 264.7 | 4 | Chemie (7M6) | |||
| 4 | C, A, D, B | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 5 | C, A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | C, A, D, B | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) | |||
| 7 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 8 | C | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 9 | C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 10 | water | water | 18.0 | 1160 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 117 (UniProt: P19491)
A, B, C, D: 120 - 264 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Ala 2 | - | cloning artifact |
| Tyr 94 | Leu 504 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
| Ser 242 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 117206.9 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 4161.2 | |
| All* | Total formula weight | 121368.1 |
