Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5O9A

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504Y-N775S) in complex with glutamate and BPAM121 at 1.78 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 301

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH427
A	HOH435
A	HOH484

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	HOH448
A	LYS82
A	LYS116
A	HOH426

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 303

Chain	Residue
A	LYS240
B	ARG149
B	HOH411

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 304

Chain	Residue
A	ARG148
A	TRP159
A	ARG163

site_id	AC5
Number of Residues	12
Details	binding site for residue 7M6 A 305

Chain	Residue
A	LYS104
A	PRO105
A	PHE106
A	MET107
A	SER108
A	SER242
B	PRO105
B	SER108
B	SER217
B	LYS218
B	GLY219
B	7M6304

site_id	AC6
Number of Residues	1
Details	binding site for residue CL A 306

Chain	Residue
A	THR5

site_id	AC7
Number of Residues	4
Details	binding site for residue CL A 308

Chain	Residue
A	SER123
A	ALA124
A	LEU215
A	HOH643

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL A 309

Chain	Residue
A	LYS253
A	HOH543
A	HOH584

site_id	AC9
Number of Residues	13
Details	binding site for residue GLU A 310

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193
A	TYR220
A	HOH456
A	HOH500
A	HOH528

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL A 311

Chain	Residue
A	MET19
A	HIS23
A	ARG31
A	HOH409
A	HOH526
D	LYS258

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO B 301

Chain	Residue
A	HIS46
A	LEU236
A	LYS240
B	TYR94
B	HOH410

site_id	AD3
Number of Residues	5
Details	binding site for residue SO4 B 302

Chain	Residue
B	SER140
B	LYS144
B	ARG148
B	HOH407
B	HOH414

site_id	AD4
Number of Residues	3
Details	binding site for residue SO4 B 303

Chain	Residue
B	ARG148
B	TRP159
B	ARG163

site_id	AD5
Number of Residues	12
Details	binding site for residue 7M6 B 304

Chain	Residue
A	PRO105
A	SER108
A	SER217
A	LYS218
A	GLY219
A	7M6305
B	LYS104
B	PRO105
B	PHE106
B	MET107
B	SER108
B	SER242

site_id	AD6
Number of Residues	1
Details	binding site for residue CL B 305

Chain	Residue
B	ASN22

site_id	AD7
Number of Residues	5
Details	binding site for residue GOL B 306

Chain	Residue
B	LYS258
B	HOH409
C	MET19
C	HIS23
C	ARG31

site_id	AD8
Number of Residues	13
Details	binding site for residue GLU B 307

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH458
B	HOH478
B	HOH483

site_id	AD9
Number of Residues	8
Details	binding site for residue SO4 C 301

Chain	Residue
C	SER140
C	LYS144
C	ARG148
C	HOH429
C	HOH432
C	HOH447
C	HOH459
C	HOH626

site_id	AE1
Number of Residues	6
Details	binding site for residue SO4 C 302

Chain	Residue
B	ARG31
B	HOH484
C	LYS183
C	HOH417
C	HOH426
C	HOH558

site_id	AE2
Number of Residues	5
Details	binding site for residue SO4 C 303

Chain	Residue
C	LYS82
C	LYS116
C	HOH403
C	HOH525
C	HOH592

site_id	AE3
Number of Residues	6
Details	binding site for residue SO4 C 304

Chain	Residue
C	ARG148
C	TRP159
C	ARG163
C	HOH416
C	HOH420
C	HOH486

site_id	AE4
Number of Residues	7
Details	binding site for residue SO4 C 305

Chain	Residue
C	SER194
C	GLU198
C	LYS210
C	ASN214
C	HOH401
C	HOH404
C	HOH442

site_id	AE5
Number of Residues	6
Details	binding site for residue SO4 C 306

Chain	Residue
C	MET107
C	SER108
C	7M6307
C	HOH452
C	HOH477
D	SER217

site_id	AE6
Number of Residues	13
Details	binding site for residue 7M6 C 307

Chain	Residue
C	LYS104
C	PRO105
C	PHE106
C	MET107
C	SER108
C	SER242
C	SO4306
D	PRO105
D	SER108
D	SER217
D	LYS218
D	GLY219
D	7M6305

site_id	AE7
Number of Residues	1
Details	binding site for residue CL C 308

Chain	Residue
C	THR5

site_id	AE8
Number of Residues	9
Details	binding site for residue CIT C 309

Chain	Residue
C	ARG148
C	ARG149
C	SER150
C	LYS151
C	ASP156
C	GOL310
C	HOH416
C	HOH423
C	HOH496

site_id	AE9
Number of Residues	6
Details	binding site for residue GOL C 310

Chain	Residue
C	ASP156
C	TRP159
C	THR160
C	CIT309
C	HOH416
C	HOH489

site_id	AF1
Number of Residues	4
Details	binding site for residue PEG C 311

Chain	Residue
C	GLY28
C	ARG31
C	LYS52
C	HOH602

site_id	AF2
Number of Residues	13
Details	binding site for residue GLU C 312

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	GLY141
C	SER142
C	THR143
C	GLU193
C	TYR220
C	HOH455
C	HOH469
C	HOH500

site_id	AF3
Number of Residues	6
Details	binding site for residue SO4 D 301

Chain	Residue
A	LYS183
D	ARG31
D	HOH444
D	HOH457
D	HOH460
D	HOH470

site_id	AF4
Number of Residues	6
Details	binding site for residue SO4 D 302

Chain	Residue
D	ASP139
D	SER140
D	LYS144
D	ARG148
D	HOH410
D	HOH436

site_id	AF5
Number of Residues	6
Details	binding site for residue SO4 D 303

Chain	Residue
D	SER194
D	GLU198
D	ASN214
D	HOH401
D	HOH402
D	HOH453

site_id	AF6
Number of Residues	4
Details	binding site for residue SO4 D 304

Chain	Residue
D	ARG148
D	TRP159
D	ARG163
D	HOH562

site_id	AF7
Number of Residues	12
Details	binding site for residue 7M6 D 305

Chain	Residue
C	PRO105
C	SER108
C	SER217
C	LYS218
C	GLY219
C	7M6307
D	LYS104
D	PRO105
D	PHE106
D	MET107
D	SER108
D	SER242

site_id	AF8
Number of Residues	2
Details	binding site for residue CL D 306

Chain	Residue
D	HIS46
D	HOH542

site_id	AF9
Number of Residues	1
Details	binding site for residue CL D 307

Chain	Residue
D	ASN22

site_id	AG1
Number of Residues	12
Details	binding site for residue GLU D 308

Chain	Residue
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	GLY141
D	SER142
D	THR143
D	GLU193
D	HOH462
D	HOH469
D	HOH471

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:11086992, ECO:0000269\|PubMed:16483599, ECO:0007744\|PDB:1FTJ, ECO:0007744\|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
D	PRO89
A	THR91
D	THR91
D	ARG96
D	SER142
D	THR143
D	GLU193
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ARG64
D	ARG64
D	ARG148
D	LYS240
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121
D	ILE121

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150
D	SER150

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184
D	SER184

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3
D	ASN3

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)