5NU1
Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Nuclear receptor ROR-gamma | polymer | 257 | 29739.3 | 2 | UniProt (P51449) Pfam (PF00104) In PDB | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | P, Q | Nuclear receptor-interacting protein 1 | polymer | 20 | 2319.6 | 2 | UniProt (P48552) In PDB | Homo sapiens (Human) | Nuclear factor RIP140,Receptor-interacting protein 140 |
| 3 | A, B | ~{N}-[4-(3-chlorophenyl)-5-(2-chlorophenyl)carbonyl-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)ethanamide | non-polymer | 559.5 | 2 | Chemie (8YB) | |||
| 4 | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A, B: 263 - 518 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 262 | - | expression tag |
| Ser 455 | Cys 455 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64117.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1119.0 | |
| All* | Total formula weight | 65236.8 |
