5NTW
Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nuclear receptor ROR-gamma | polymer | 257 | 29739.3 | 4 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | E, F, G, H (P, Q, R, S) | Nuclear receptor-interacting protein 1 | polymer | 20 | 2319.6 | 4 | UniProt (P48552) | Homo sapiens (Human) | Nuclear factor RIP140,Receptor-interacting protein 140 |
| 3 | I, J, K, L (A, B, C, D) | (S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-isopropyl-6-(((1r,4S)-4-(trifluoromethyl)cyclohexyl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamide | non-polymer | 552.7 | 4 | Chemie (98N) | |||
| 4 | M, N, O, P, Q... (A, B, C, D, Q...) | water | water | 18.0 | 1026 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 263 - 518 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 262 | - | expression tag |
| Ser 455 | Cys 455 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 128235.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2210.6 | |
| All* | Total formula weight | 130446.3 |
