5NTC
Crystal structure of mouse CARM1 in complex with inhibitor SA0678
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-arginine methyltransferase CARM1 | polymer | 371 | 41985.6 | 4 | UniProt (Q9WVG6) Pfam (PF06325) Pfam (PF22528) | Mus musculus (house Mouse) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
| 2 | E, F, G, M, N... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 3 | AA, H (D, A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 4 | I, X (A, C) | 1,2-DIMETHOXYETHANE | non-polymer | 90.1 | 2 | Chemie (DXE) | |||
| 5 | J (A) | 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE | non-polymer | 134.2 | 1 | Chemie (M2M) | |||
| 6 | BA, K, R (D, A, B) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 3 | Chemie (B3P) | |||
| 7 | CA, L, S, Y (D, A, B, C) | [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(2-azaniumylethyl)-[(3~{S})-3-azaniumyl-4-oxidanyl-4-oxidanylidene-butyl]azanium | non-polymer | 413.5 | 4 | Chemie (6L7) | |||
| 8 | DA, EA, FA, GA (A, B, C, D) | water | water | 18.0 | 574 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 130 - 497 (UniProt: Q9WVG6)
| PDB | External Database | Details |
|---|---|---|
| Gly 127 | - | expression tag |
| His 128 | - | expression tag |
| Met 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 167942.5 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 3834.3 | |
| All* | Total formula weight | 171776.9 |
