5NNC
Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 2 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
| 2 | C, D | Histone H3 | polymer | 17 | 1993.3 | 2 | UniProt (Q5TEC6) UniProt (by SIFTS) (P68431) In PDB | Homo sapiens | |
| 3 | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A, B: 44 - 168 (UniProt: O60885)
C, D: 4 - 20 (UniProt: Q5TEC6)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Tyr 20 | Leu 21 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 34185.3 | |
| All* | Total formula weight | 34185.3 |
