5NIH
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A | Glutamate receptor 2 | polymer | 264 | 29278.7 | 2 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | B, A | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | B, A | (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid | non-polymer | 213.2 | 2 | Chemie (8VE) | |||
| 4 | B, A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | B, A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 7 | water | water | 18.0 | 779 | Chemie (HOH) |
Sequence modifications
B, A: 3 - 117 (UniProt: P19491)
B, A: 120 - 264 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Ala 2 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58557.5 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1405.0 | |
| All* | Total formula weight | 59962.5 |
