5NIH
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| A | HIS46 |
| B | HOH570 |
| A | LYS240 |
| A | HOH407 |
| A | HOH708 |
| B | HIS23 |
| B | ARG31 |
| B | HOH421 |
| B | HOH456 |
| B | HOH466 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | ASN29 |
| B | GLU30 |
| B | ARG149 |
| B | HOH403 |
| B | HOH558 |
| B | HOH569 |
| B | HOH645 |
| B | HOH710 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue 8VE B 303 |
| Chain | Residue |
| B | GLU13 |
| B | TYR61 |
| B | PRO89 |
| B | THR91 |
| B | ARG96 |
| B | LEU138 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| B | THR174 |
| B | GLU193 |
| B | MET196 |
| B | HOH484 |
| B | HOH519 |
| B | HOH578 |
| B | HOH605 |
| B | HOH606 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 304 |
| Chain | Residue |
| A | HOH403 |
| A | HOH708 |
| B | ARG31 |
| B | LYS151 |
| B | HOH644 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 305 |
| Chain | Residue |
| B | ALA153 |
| B | HOH431 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | ASN22 |
| A | ARG64 |
| A | HOH587 |
| A | HOH627 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | HIS23 |
| A | ARG31 |
| A | HOH419 |
| A | HOH449 |
| A | HOH470 |
| A | HOH480 |
| B | HIS46 |
| B | LYS240 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | GLU97 |
| A | ASP101 |
| A | PHE102 |
| A | HOH411 |
| A | HOH416 |
| A | HOH463 |
| A | HOH582 |
| B | LYS104 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | binding site for residue 8VE A 304 |
| Chain | Residue |
| A | GLU13 |
| A | TYR61 |
| A | PRO89 |
| A | THR91 |
| A | ARG96 |
| A | LEU138 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | THR174 |
| A | GLU193 |
| A | MET196 |
| A | HOH445 |
| A | HOH447 |
| A | HOH530 |
| A | HOH559 |
| A | HOH637 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | LYS117 |
| A | GLU201 |
| A | GLN202 |
| A | CYS261 |
| A | HOH454 |
| B | HOH753 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | LEU12 |
| A | GLY59 |
| A | HOH410 |
| A | HOH432 |
| A | HOH437 |
| A | HOH452 |
| A | HOH508 |
| A | HOH598 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | HOH677 |
| A | GLU27 |
| A | ASN29 |
| A | GLU30 |
| A | ARG148 |
| A | ARG149 |
| A | HOH574 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 308 |
| Chain | Residue |
| A | ARG148 |
| A | TRP159 |
| A | ARG163 |
| A | HOH626 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 309 |
| Chain | Residue |
| A | ALA153 |
| A | HOH605 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
