5NIH

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue SO4 B 301

Chain	Residue
A	HIS46
B	HOH570
A	LYS240
A	HOH407
A	HOH708
B	HIS23
B	ARG31
B	HOH421
B	HOH456
B	HOH466

---

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 B 302

Chain	Residue
B	ASN29
B	GLU30
B	ARG149
B	HOH403
B	HOH558
B	HOH569
B	HOH645
B	HOH710

---

site_id	AC3
Number of Residues	17
Details	binding site for residue 8VE B 303

Chain	Residue
B	GLU13
B	TYR61
B	PRO89
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	THR174
B	GLU193
B	MET196
B	HOH484
B	HOH519
B	HOH578
B	HOH605
B	HOH606

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL B 304

Chain	Residue
A	HOH403
A	HOH708
B	ARG31
B	LYS151
B	HOH644

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CL B 305

Chain	Residue
B	ALA153
B	HOH431

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 301

Chain	Residue
A	ASN22
A	ARG64
A	HOH587
A	HOH627

---

site_id	AC7
Number of Residues	8
Details	binding site for residue SO4 A 302

Chain	Residue
A	HIS23
A	ARG31
A	HOH419
A	HOH449
A	HOH470
A	HOH480
B	HIS46
B	LYS240

---

site_id	AC8
Number of Residues	8
Details	binding site for residue SO4 A 303

Chain	Residue
A	GLU97
A	ASP101
A	PHE102
A	HOH411
A	HOH416
A	HOH463
A	HOH582
B	LYS104

---

site_id	AC9
Number of Residues	17
Details	binding site for residue 8VE A 304

Chain	Residue
A	GLU13
A	TYR61
A	PRO89
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	THR174
A	GLU193
A	MET196
A	HOH445
A	HOH447
A	HOH530
A	HOH559
A	HOH637

---

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL A 305

Chain	Residue
A	LYS117
A	GLU201
A	GLN202
A	CYS261
A	HOH454
B	HOH753

---

site_id	AD2
Number of Residues	8
Details	binding site for residue GOL A 306

Chain	Residue
A	LEU12
A	GLY59
A	HOH410
A	HOH432
A	HOH437
A	HOH452
A	HOH508
A	HOH598

---

site_id	AD3
Number of Residues	7
Details	binding site for residue GOL A 307

Chain	Residue
A	HOH677
A	GLU27
A	ASN29
A	GLU30
A	ARG148
A	ARG149
A	HOH574

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ACT A 308

Chain	Residue
A	ARG148
A	TRP159
A	ARG163
A	HOH626

---

site_id	AD5
Number of Residues	2
Details	binding site for residue CL A 309

Chain	Residue
A	ALA153
A	HOH605

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
B	PRO89
A	SER142
A	THR143
A	GLU193
B	THR91
B	ARG96
B	SER142
B	THR143
B	GLU193
A	PRO89
A	THR91
A	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ARG64
B	ARG148
B	LYS240
A	ARG64
A	ARG148
A	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ILE121
A	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER150
A	SER150

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER184
A	SER184

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN3
A	ASN3

---