5NI4
Crystal structure of human LTA4H mutant E271A in complex with LTA4 (crystal form II)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Leukotriene A-4 hydrolase | polymer | 617 | 70134.8 | 3 | UniProt (P09960) Pfam (PF17900) Pfam (PF01433) Pfam (PF09127) | Homo sapiens (Human) | LTA-4 hydrolase,Leukotriene A(4) hydrolase |
| 2 | D, I, N (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E, F, G, J, K... (A, B, C) | IMIDAZOLE | non-polymer | 69.1 | 7 | Chemie (IMD) | |||
| 4 | H, M, P (A, B, C) | 5S-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid | non-polymer | 318.4 | 3 | Chemie (DJ3) | |||
| 5 | Q, R, S (A, B, C) | water | water | 18.0 | 2056 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 610 (UniProt: P09960)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 271 | Glu 272 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 210404.5 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1635.2 | |
| All* | Total formula weight | 212039.6 |
