5NGE
Crystal structure of USP7 in complex with the non-covalent inhibitor, FT671
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Ubiquitin carboxyl-terminal hydrolase 7 | polymer | 355 | 41148.5 | 2 | UniProt (Q93009) Pfam (PF00443) In PDB | Homo sapiens (Human) | Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7 |
| 2 | A, B | 5-[[1-[(3~{S})-4,4-bis(fluoranyl)-3-(3-fluoranylpyrazol-1-yl)butanoyl]-4-oxidanyl-piperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one | non-polymer | 533.5 | 2 | Chemie (8WK) | |||
| 3 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A, B: 208 - 560 (UniProt: Q93009)
| PDB | External Database | Details |
|---|---|---|
| Gly 206 | - | expression tag |
| Ser 207 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82296.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1067.0 | |
| All* | Total formula weight | 83363.9 |
