5NG5

multi-drug efflux; membrane transport; RND superfamily; Drug resistance

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (E, D, G, H, A...)	Multidrug efflux pump subunit AcrA	polymer	373	39800.7	6	UniProt (P0AE06) Pfam (PF25917) Pfam (PF25876) Pfam (PF25944) Pfam (PF25967)	Escherichia coli	AcrAB-TolC multidrug efflux pump subunit AcrA,Acridine resistance protein A
2	G, H, I (F, I, C)	Outer membrane protein TolC	polymer	493	53783.4	3	UniProt (P02930) Pfam (PF02321)	Escherichia coli	Multidrug efflux pump subunit TolC,Outer membrane factor TolC
3	J, K, O (K, L, J)	Multidrug efflux pump subunit AcrB	polymer	1049	113665.2	3	UniProt (P31224) Pfam (PF00873)	Escherichia coli	AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B
4	L, M, N (M, N, O)	Multidrug efflux pump accessory protein AcrZ	polymer	54	5995.2	3	UniProt (P0AAW9) Pfam (PF10766)	Escherichia coli	AcrAB-TolC multidrug efflux pump accessory protein AcrZ,Acridine resistance protein Z
5	P, Q, R (K, L, J)	6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile	non-polymer		526.7	3	Chemie (5QF)

Sequence modifications

E, D, G, H, A, B: 25 - 397 (UniProt: P0AE06)

PDB	External Database	Details
Met 223	Phe 223	conflict
Met 224	Leu 224	conflict
Met 287	Leu 287	conflict
Met 288	Leu 288	conflict

M, N, O: 1 - 49 (UniProt: P0AAW9)

PDB	External Database	Details
His 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	759135.0
Non-Polymers*	Number of molecules	3
	Total formula weight	1580.1
All*	Total formula weight	760715.1

*Water molecules are not included.