Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5NG5

multi-drug efflux; membrane transport; RND superfamily; Drug resistance

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015567	molecular_function	alkane transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0015895	biological_process	alkane transport
A	0015908	biological_process	fatty acid transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990281	cellular_component	efflux pump complex
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015567	molecular_function	alkane transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0015895	biological_process	alkane transport
B	0015908	biological_process	fatty acid transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990281	cellular_component	efflux pump complex
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0019867	cellular_component	outer membrane
C	0055085	biological_process	transmembrane transport
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0009410	biological_process	response to xenobiotic stimulus
D	0009636	biological_process	response to toxic substance
D	0015125	molecular_function	bile acid transmembrane transporter activity
D	0015567	molecular_function	alkane transmembrane transporter activity
D	0015721	biological_process	bile acid and bile salt transport
D	0015895	biological_process	alkane transport
D	0015908	biological_process	fatty acid transport
D	0016020	cellular_component	membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0030288	cellular_component	outer membrane-bounded periplasmic space
D	0042802	molecular_function	identical protein binding
D	0042908	biological_process	xenobiotic transport
D	0046677	biological_process	response to antibiotic
D	0055085	biological_process	transmembrane transport
D	0098567	cellular_component	periplasmic side of plasma membrane
D	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
D	1990281	cellular_component	efflux pump complex
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0009410	biological_process	response to xenobiotic stimulus
E	0009636	biological_process	response to toxic substance
E	0015125	molecular_function	bile acid transmembrane transporter activity
E	0015567	molecular_function	alkane transmembrane transporter activity
E	0015721	biological_process	bile acid and bile salt transport
E	0015895	biological_process	alkane transport
E	0015908	biological_process	fatty acid transport
E	0016020	cellular_component	membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0030288	cellular_component	outer membrane-bounded periplasmic space
E	0042802	molecular_function	identical protein binding
E	0042908	biological_process	xenobiotic transport
E	0046677	biological_process	response to antibiotic
E	0055085	biological_process	transmembrane transport
E	0098567	cellular_component	periplasmic side of plasma membrane
E	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
E	1990281	cellular_component	efflux pump complex
F	0015562	molecular_function	efflux transmembrane transporter activity
F	0019867	cellular_component	outer membrane
F	0055085	biological_process	transmembrane transport
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0009410	biological_process	response to xenobiotic stimulus
G	0009636	biological_process	response to toxic substance
G	0015125	molecular_function	bile acid transmembrane transporter activity
G	0015567	molecular_function	alkane transmembrane transporter activity
G	0015721	biological_process	bile acid and bile salt transport
G	0015895	biological_process	alkane transport
G	0015908	biological_process	fatty acid transport
G	0016020	cellular_component	membrane
G	0022857	molecular_function	transmembrane transporter activity
G	0030288	cellular_component	outer membrane-bounded periplasmic space
G	0042802	molecular_function	identical protein binding
G	0042908	biological_process	xenobiotic transport
G	0046677	biological_process	response to antibiotic
G	0055085	biological_process	transmembrane transport
G	0098567	cellular_component	periplasmic side of plasma membrane
G	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
G	1990281	cellular_component	efflux pump complex
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0009410	biological_process	response to xenobiotic stimulus
H	0009636	biological_process	response to toxic substance
H	0015125	molecular_function	bile acid transmembrane transporter activity
H	0015567	molecular_function	alkane transmembrane transporter activity
H	0015721	biological_process	bile acid and bile salt transport
H	0015895	biological_process	alkane transport
H	0015908	biological_process	fatty acid transport
H	0016020	cellular_component	membrane
H	0022857	molecular_function	transmembrane transporter activity
H	0030288	cellular_component	outer membrane-bounded periplasmic space
H	0042802	molecular_function	identical protein binding
H	0042908	biological_process	xenobiotic transport
H	0046677	biological_process	response to antibiotic
H	0055085	biological_process	transmembrane transport
H	0098567	cellular_component	periplasmic side of plasma membrane
H	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
H	1990281	cellular_component	efflux pump complex
I	0015562	molecular_function	efflux transmembrane transporter activity
I	0019867	cellular_component	outer membrane
I	0055085	biological_process	transmembrane transport
J	0005515	molecular_function	protein binding
J	0005886	cellular_component	plasma membrane
J	0009410	biological_process	response to xenobiotic stimulus
J	0009636	biological_process	response to toxic substance
J	0015125	molecular_function	bile acid transmembrane transporter activity
J	0015562	molecular_function	efflux transmembrane transporter activity
J	0015567	molecular_function	alkane transmembrane transporter activity
J	0015721	biological_process	bile acid and bile salt transport
J	0015895	biological_process	alkane transport
J	0015908	biological_process	fatty acid transport
J	0016020	cellular_component	membrane
J	0022857	molecular_function	transmembrane transporter activity
J	0042802	molecular_function	identical protein binding
J	0042908	biological_process	xenobiotic transport
J	0042910	molecular_function	xenobiotic transmembrane transporter activity
J	0042930	biological_process	enterobactin transport
J	0042931	molecular_function	enterobactin transmembrane transporter activity
J	0046677	biological_process	response to antibiotic
J	0055085	biological_process	transmembrane transport
J	0098567	cellular_component	periplasmic side of plasma membrane
J	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
J	1990281	cellular_component	efflux pump complex
K	0005515	molecular_function	protein binding
K	0005886	cellular_component	plasma membrane
K	0009410	biological_process	response to xenobiotic stimulus
K	0009636	biological_process	response to toxic substance
K	0015125	molecular_function	bile acid transmembrane transporter activity
K	0015562	molecular_function	efflux transmembrane transporter activity
K	0015567	molecular_function	alkane transmembrane transporter activity
K	0015721	biological_process	bile acid and bile salt transport
K	0015895	biological_process	alkane transport
K	0015908	biological_process	fatty acid transport
K	0016020	cellular_component	membrane
K	0022857	molecular_function	transmembrane transporter activity
K	0042802	molecular_function	identical protein binding
K	0042908	biological_process	xenobiotic transport
K	0042910	molecular_function	xenobiotic transmembrane transporter activity
K	0042930	biological_process	enterobactin transport
K	0042931	molecular_function	enterobactin transmembrane transporter activity
K	0046677	biological_process	response to antibiotic
K	0055085	biological_process	transmembrane transport
K	0098567	cellular_component	periplasmic side of plasma membrane
K	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
K	1990281	cellular_component	efflux pump complex
L	0005515	molecular_function	protein binding
L	0005886	cellular_component	plasma membrane
L	0009410	biological_process	response to xenobiotic stimulus
L	0009636	biological_process	response to toxic substance
L	0015125	molecular_function	bile acid transmembrane transporter activity
L	0015562	molecular_function	efflux transmembrane transporter activity
L	0015567	molecular_function	alkane transmembrane transporter activity
L	0015721	biological_process	bile acid and bile salt transport
L	0015895	biological_process	alkane transport
L	0015908	biological_process	fatty acid transport
L	0016020	cellular_component	membrane
L	0022857	molecular_function	transmembrane transporter activity
L	0042802	molecular_function	identical protein binding
L	0042908	biological_process	xenobiotic transport
L	0042910	molecular_function	xenobiotic transmembrane transporter activity
L	0042930	biological_process	enterobactin transport
L	0042931	molecular_function	enterobactin transmembrane transporter activity
L	0046677	biological_process	response to antibiotic
L	0055085	biological_process	transmembrane transport
L	0098567	cellular_component	periplasmic side of plasma membrane
L	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
L	1990281	cellular_component	efflux pump complex
M	0005515	molecular_function	protein binding
M	0005886	cellular_component	plasma membrane
M	0009279	cellular_component	cell outer membrane
M	0042910	molecular_function	xenobiotic transmembrane transporter activity
M	0046677	biological_process	response to antibiotic
M	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
N	0005515	molecular_function	protein binding
N	0005886	cellular_component	plasma membrane
N	0009279	cellular_component	cell outer membrane
N	0042910	molecular_function	xenobiotic transmembrane transporter activity
N	0046677	biological_process	response to antibiotic
N	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
O	0005515	molecular_function	protein binding
O	0005886	cellular_component	plasma membrane
O	0009279	cellular_component	cell outer membrane
O	0042910	molecular_function	xenobiotic transmembrane transporter activity
O	0046677	biological_process	response to antibiotic
O	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue 5QF J 1101

Chain	Residue
J	PHE136
J	GLY288
J	PRO326
J	TYR327
J	VAL571
J	MET573
J	PHE610
J	VAL612
J	PHE615
J	PHE617
J	PHE628
J	VAL139
J	LEU668
J	GLN151
J	PHE178
J	GLY179
J	ILE277
J	ALA279
J	ALA286
J	SER287

site_id	AC2
Number of Residues	16
Details	binding site for Di-peptide 5QF K 1101 and PHE K 628

Chain	Residue
K	PHE136
K	VAL139
K	GLN176
K	PHE178
K	GLY179
K	ILE277
K	ALA279
K	PRO326
K	MET573
K	VAL609
K	PHE610
K	VAL612
K	PHE615
K	ALA627
K	VAL629
K	LEU668

site_id	AC3
Number of Residues	16
Details	binding site for Di-peptide 5QF K 1101 and PHE K 628

Chain	Residue
K	PHE136
K	VAL139
K	GLN176
K	PHE178
K	GLY179
K	ILE277
K	ALA279
K	PRO326
K	MET573
K	VAL609
K	PHE610
K	VAL612
K	PHE615
K	ALA627
K	VAL629
K	LEU668

site_id	AC4
Number of Residues	16
Details	binding site for Di-peptide 5QF K 1101 and PHE K 628

Chain	Residue
K	PHE136
K	VAL139
K	GLN176
K	PHE178
K	GLY179
K	ILE277
K	ALA279
K	PRO326
K	MET573
K	VAL609
K	PHE610
K	VAL612
K	PHE615
K	ALA627
K	VAL629
K	LEU668

site_id	AC5
Number of Residues	14
Details	binding site for Di-peptide 5QF L 1101 and PHE L 628

Chain	Residue
L	PHE136
L	VAL139
L	PHE178
L	GLY179
L	ILE277
L	PRO326
L	MET573
L	VAL609
L	PHE610
L	PHE615
L	ARG620
L	ALA627
L	VAL629
L	LEU668

site_id	AC6
Number of Residues	16
Details	binding site for Di-peptide 5QF L 1101 and PHE L 610

Chain	Residue
L	PHE136
L	VAL139
L	PHE178
L	GLY179
L	ILE277
L	GLU280
L	PHE281
L	PRO326
L	MET573
L	VAL609
L	ALA611
L	PHE615
L	ARG620
L	ALA627
L	PHE628
L	LEU668

site_id	AC7
Number of Residues	14
Details	binding site for Di-peptide 5QF L 1101 and PHE L 628

Chain	Residue
L	VAL139
L	PHE178
L	GLY179
L	ILE277
L	PRO326
L	MET573
L	VAL609
L	PHE610
L	PHE615
L	ARG620
L	ALA627
L	VAL629
L	LEU668
L	PHE136

site_id	AC8
Number of Residues	14
Details	binding site for Di-peptide 5QF L 1101 and PHE L 628

Chain	Residue
L	PHE136
L	VAL139
L	PHE178
L	GLY179
L	ILE277
L	PRO326
L	MET573
L	VAL609
L	PHE610
L	PHE615
L	ARG620
L	ALA627
L	VAL629
L	LEU668

site_id	AC9
Number of Residues	14
Details	binding site for Di-peptide 5QF L 1101 and PHE L 178

Chain	Residue
L	PHE136
L	VAL139
L	LEU177
L	GLY179
L	ILE277
L	GLY288
L	LEU289
L	PRO326
L	MET573
L	PHE610
L	PHE615
L	ARG620
L	PHE628
L	LEU668

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	TOPO_DOM: Periplasmic => ECO:0000305

Chain	Residue	Details
M	MET1-SER7
L	GLU414-ILE438
L	ALA491-THR538
L	ALA889-PRO898
L	LEU944-LEU972
L	ILE1019-HIS1049
J	MET1-PRO9
J	LEU357-THR365
J	GLU414-ILE438
J	ALA491-THR538
J	ALA889-PRO898
N	MET1-SER7
J	LEU944-LEU972
J	ILE1019-HIS1049
O	MET1-SER7
K	ALA491-THR538
K	ALA889-PRO898
K	LEU944-LEU972
K	ILE1019-HIS1049
L	MET1-PRO9
L	LEU357-THR365

site_id	SWS_FT_FI2
Number of Residues	60
Details	TRANSMEM: Helical => ECO:0000255\|HAMAP-Rule:MF_01484

Chain	Residue	Details
M	LEU8-GLY28
N	LEU8-GLY28
O	LEU8-GLY28

site_id	SWS_FT_FI3
Number of Residues	60
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
M	LEU29-HIS49
L	PHE556-ASN871
L	ARG919-ASP924
L	THR993-GLY998
J	LYS29-SER336
J	PHE386-ASN391
J	PHE458-ALA465
J	PHE556-ASN871
J	ARG919-ASP924
J	THR993-GLY998
N	LEU29-HIS49
O	LEU29-HIS49
K	PHE556-ASN871
K	ARG919-ASP924
K	THR993-GLY998
L	LYS29-SER336
L	PHE386-ASN391
L	PHE458-ALA465

site_id	SWS_FT_FI4
Number of Residues	57
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
K	ILE337-TYR356
L	ILE337-TYR356
J	ILE337-TYR356

site_id	SWS_FT_FI5
Number of Residues	57
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
K	LEU366-ALA385
L	LEU366-ALA385
J	LEU366-ALA385

site_id	SWS_FT_FI6
Number of Residues	63
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
K	THR392-VAL413
L	THR392-VAL413
J	THR392-VAL413

site_id	SWS_FT_FI7
Number of Residues	54
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
K	GLN439-ALA457
L	GLN439-ALA457
J	GLN439-ALA457

site_id	SWS_FT_FI8
Number of Residues	72
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
K	ILE466-PRO490
L	ILE466-PRO490
J	ILE466-PRO490

site_id	SWS_FT_FI9
Number of Residues	48
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
K	GLY539-LEU555
L	GLY539-LEU555
J	GLY539-LEU555

site_id	SWS_FT_FI10
Number of Residues	48
Details	TRANSMEM: Helical; Name=8

Chain	Residue	Details
K	GLN872-LEU888
L	GLN872-LEU888
J	GLN872-LEU888

site_id	SWS_FT_FI11
Number of Residues	57
Details	TRANSMEM: Helical; Name=9

Chain	Residue	Details
K	PHE899-PHE918
L	PHE899-PHE918
J	PHE899-PHE918

site_id	SWS_FT_FI12
Number of Residues	54
Details	TRANSMEM: Helical; Name=10

Chain	Residue	Details
K	VAL925-ILE943
L	VAL925-ILE943
J	VAL925-ILE943

site_id	SWS_FT_FI13
Number of Residues	57
Details	TRANSMEM: Helical; Name=11

Chain	Residue	Details
K	ARG973-SER992
L	ARG973-SER992
J	ARG973-SER992

site_id	SWS_FT_FI14
Number of Residues	57
Details	TRANSMEM: Helical; Name=12

Chain	Residue	Details
K	ALA999-ALA1018
L	ALA999-ALA1018
J	ALA999-ALA1018

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)