5NG3

Structure of inactive kinase RIP2K(K47R)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (D, A)	Receptor-interacting serine/threonine-protein kinase 2	polymer	304	34919.9	2	UniProt (O43353) Pfam (PF07714)	Homo sapiens (Human)	CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD-containing IL-1 beta ICE-kinase,RIP-like-interacting CLARP kinase,Receptor-interacting protein 2,RIP-2,Tyrosine-protein kinase RIPK2
2	B, D (B, C)	Receptor-interacting serine/threonine-protein kinase 2	polymer	304	34840.0	2	UniProt (O43353) Pfam (PF07714)	Homo sapiens (Human)	CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD-containing IL-1 beta ICE-kinase,RIP-like-interacting CLARP kinase,Receptor-interacting protein 2,RIP-2,Tyrosine-protein kinase RIPK2
3	E, F, G, H, I... (D, B, A, C)	SULFATE ION	non-polymer		96.1	22	Chemie (SO4)
4	AA, BA, CA, DA (D, B, A, C)	water	water		18.0	53	Chemie (HOH)

Sequence modifications

D, A: 1 - 300 (UniProt: O43353)

PDB	External Database	Details
Gly -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag
Arg 47	Lys 47	engineered mutation

B, C: 1 - 300 (UniProt: O43353)

PDB	External Database	Details
Gly -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag
Arg 47	Lys 47	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	139519.8
Non-Polymers*	Number of molecules	22
	Total formula weight	2113.4
All*	Total formula weight	141633.2

*Water molecules are not included.