5NG3
Structure of inactive kinase RIP2K(K47R)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 401 |
| Chain | Residue |
| B | SER282 |
| B | LEU284 |
| D | PRO281 |
| D | SER282 |
| D | LYS285 |
| D | HOH508 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 402 |
| Chain | Residue |
| D | ARG47 |
| D | LYS148 |
| D | HOH501 |
| D | GLY27 |
| D | ALA28 |
| D | SER29 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 403 |
| Chain | Residue |
| A | SER271 |
| A | LYS285 |
| D | HIS16 |
| D | LYS17 |
| D | ALA38 |
| D | ASP39 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 404 |
| Chain | Residue |
| D | VAL32 |
| D | TYR97 |
| D | MET98 |
| D | LEU153 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 405 |
| Chain | Residue |
| D | VAL32 |
| D | ARG47 |
| D | LEU79 |
| D | THR95 |
| D | ASP164 |
| D | SO4406 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 406 |
| Chain | Residue |
| D | LEU79 |
| D | ILE81 |
| D | ILE93 |
| D | ALA163 |
| D | ASP164 |
| D | PHE165 |
| D | SO4405 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | GLY27 |
| B | ALA28 |
| B | SER29 |
| B | ARG47 |
| B | LYS148 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | ILE250 |
| B | ARG262 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | PRO281 |
| B | SER282 |
| B | LYS285 |
| B | HOH504 |
| D | SER282 |
| D | HOH506 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | ALA19 |
| B | ASP20 |
| C | ALA263 |
| C | ARG264 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | LEU24 |
| B | TYR97 |
| B | MET98 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 406 |
| Chain | Residue |
| B | VAL32 |
| B | ARG47 |
| B | THR95 |
| B | ALA163 |
| B | ASP164 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 407 |
| Chain | Residue |
| B | ALA19 |
| B | ASP20 |
| B | ARG36 |
| C | ARG264 |
| C | GLU289 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | GLY27 |
| A | ALA28 |
| A | SER29 |
| A | ARG47 |
| A | ASP146 |
| A | LYS148 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ILE250 |
| A | ASN251 |
| A | ARG262 |
| A | SO4403 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | ILE266 |
| A | GLU270 |
| A | SO4402 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | GLU66 |
| A | LEU70 |
| A | GLY166 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 401 |
| Chain | Residue |
| A | SER282 |
| A | LEU284 |
| C | SER282 |
| C | LEU284 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 402 |
| Chain | Residue |
| C | GLY27 |
| C | ALA28 |
| C | SER29 |
| C | ARG47 |
| C | LYS148 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 C 403 |
| Chain | Residue |
| B | HIS16 |
| B | LYS17 |
| B | ALA38 |
| B | ASP39 |
| C | SER271 |
| C | PRO281 |
| C | LYS285 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 404 |
| Chain | Residue |
| C | LEU24 |
| C | MET98 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 405 |
| Chain | Residue |
| C | ILE250 |
| C | ASN251 |
| C | ARG262 |
| site_id | AE5 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide ARG A 205 and ASP C 231 |
| Chain | Residue |
| A | HIS145 |
| A | MET172 |
| A | PRO200 |
| A | GLY201 |
| A | LYS203 |
| A | SER204 |
| A | ALA206 |
| A | SER207 |
| A | PHE229 |
| A | GLU230 |
| A | VAL232 |
| A | THR233 |
| C | PHE229 |
| C | GLU230 |
| C | VAL232 |
| C | THR233 |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LlHhDLKtqNILL |
| Chain | Residue | Details |
| D | LEU142-LEU154 | |
| B | LEU142-LEU154 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | Region: {"description":"Helix alphaC","evidences":[{"source":"PubMed","id":"28545134","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"9705938","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"(Microbial infection) O-acetylthreonine; by Yersinia YopJ","evidences":[{"source":"PubMed","id":"22520462","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"28545134","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"(Microbial infection) O-acetylserine; by Yersinia YopJ","evidences":[{"source":"PubMed","id":"22520462","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"18079694","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis and LRRK2; alternate","evidences":[{"source":"PubMed","id":"16824733","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27830463","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28545134","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
