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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5NG3

Structure of inactive kinase RIP2K(K47R)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 D 401

Chain	Residue
B	SER282
B	LEU284
D	PRO281
D	SER282
D	LYS285
D	HOH508

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 D 402

Chain	Residue
D	ARG47
D	LYS148
D	HOH501
D	GLY27
D	ALA28
D	SER29

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 D 403

Chain	Residue
A	SER271
A	LYS285
D	HIS16
D	LYS17
D	ALA38
D	ASP39

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 D 404

Chain	Residue
D	VAL32
D	TYR97
D	MET98
D	LEU153

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 D 405

Chain	Residue
D	VAL32
D	ARG47
D	LEU79
D	THR95
D	ASP164
D	SO4406

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 D 406

Chain	Residue
D	LEU79
D	ILE81
D	ILE93
D	ALA163
D	ASP164
D	PHE165
D	SO4405

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 B 401

Chain	Residue
B	GLY27
B	ALA28
B	SER29
B	ARG47
B	LYS148

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 B 402

Chain	Residue
B	ILE250
B	ARG262

site_id	AC9
Number of Residues	6
Details	binding site for residue SO4 B 403

Chain	Residue
B	PRO281
B	SER282
B	LYS285
B	HOH504
D	SER282
D	HOH506

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 B 404

Chain	Residue
B	ALA19
B	ASP20
C	ALA263
C	ARG264

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 B 405

Chain	Residue
B	LEU24
B	TYR97
B	MET98

site_id	AD3
Number of Residues	5
Details	binding site for residue SO4 B 406

Chain	Residue
B	VAL32
B	ARG47
B	THR95
B	ALA163
B	ASP164

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 B 407

Chain	Residue
B	ALA19
B	ASP20
B	ARG36
C	ARG264
C	GLU289

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 A 401

Chain	Residue
A	GLY27
A	ALA28
A	SER29
A	ARG47
A	ASP146
A	LYS148

site_id	AD6
Number of Residues	4
Details	binding site for residue SO4 A 402

Chain	Residue
A	ILE250
A	ASN251
A	ARG262
A	SO4403

site_id	AD7
Number of Residues	3
Details	binding site for residue SO4 A 403

Chain	Residue
A	ILE266
A	GLU270
A	SO4402

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 A 404

Chain	Residue
A	GLU66
A	LEU70
A	GLY166

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 C 401

Chain	Residue
A	SER282
A	LEU284
C	SER282
C	LEU284

site_id	AE1
Number of Residues	5
Details	binding site for residue SO4 C 402

Chain	Residue
C	GLY27
C	ALA28
C	SER29
C	ARG47
C	LYS148

site_id	AE2
Number of Residues	7
Details	binding site for residue SO4 C 403

Chain	Residue
B	HIS16
B	LYS17
B	ALA38
B	ASP39
C	SER271
C	PRO281
C	LYS285

site_id	AE3
Number of Residues	2
Details	binding site for residue SO4 C 404

Chain	Residue
C	LEU24
C	MET98

site_id	AE4
Number of Residues	3
Details	binding site for residue SO4 C 405

Chain	Residue
C	ILE250
C	ASN251
C	ARG262

site_id	AE5
Number of Residues	16
Details	binding site for Di-peptide ARG A 205 and ASP C 231

Chain	Residue
A	HIS145
A	MET172
A	PRO200
A	GLY201
A	LYS203
A	SER204
A	ALA206
A	SER207
A	PHE229
A	GLU230
A	VAL232
A	THR233
C	PHE229
C	GLU230
C	VAL232
C	THR233

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LlHhDLKtqNILL

Chain	Residue	Details
B	LEU142-LEU154
D	LEU142-LEU154

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:9705938

Chain	Residue	Details
B	ASP146
C	ASP146

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159

Chain	Residue	Details
B	LEU24
C	LEU24

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
B	ARG47
C	ARG47

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269\|PubMed:22520462

Chain	Residue	Details
B	THR149
B	THR189
C	THR149
C	THR189

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19369195

Chain	Residue	Details
B	SER168
C	SER168

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine; alternate => ECO:0000269\|PubMed:28545134

Chain	Residue	Details
B	SER174
B	SER178
B	SER181
C	SER174
C	SER178
C	SER181

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis and LRRK2; alternate => ECO:0000269\|PubMed:16824733, ECO:0000269\|PubMed:27830463, ECO:0000269\|PubMed:28545134

Chain	Residue	Details
B	SER176
C	SER176

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:28545134

Chain	Residue	Details
B	SER180
C	SER180

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: (Microbial infection) O-acetylserine; by Yersinia YopJ => ECO:0000269\|PubMed:22520462

Chain	Residue	Details
B	SER183
C	SER183

site_id	SWS_FT_FI10
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:18079694

Chain	Residue	Details
B	LYS209
C	LYS209

223166

PDB entries from 2024-07-31

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