5NEU

Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose B.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (1)	O1 Manisa VP1	polymer	208	22850.9	1	UniProt (Q6PMW3) Pfam (PF22663)	Foot-and-mouth disease virus
2	B (2)	O1 Manisa VP2	polymer	218	24417.5	1	UniProt (Q6PMW3) Pfam (PF00073)	Foot-and-mouth disease virus
3	C (3)	Capsid protein	polymer	220	23933.9	1	UniProt (A0A1C6ZW60) Pfam (PF00073) UniProt (by SIFTS) (Q6PMW3)	Foot-and-mouth disease virus
4	D (4)	O1 Manisa VP4	polymer	85	8766.1	1	UniProt (E1ACS1) Pfam (PF08935) UniProt (by SIFTS) (D1H101)	Foot-and-mouth disease virus
5	E (A)	Integrin alpha-V	polymer	590	64937.8	1	UniProt (P06756) Pfam (PF01839) Pfam (PF08441)	Homo sapiens (Human)	Vitronectin receptor subunit alpha
6	F (B)	Integrin beta-6	polymer	470	51534.6	1	UniProt (P18564) Pfam (PF00362) Pfam (PF18372) Pfam (PF17205)	Homo sapiens (Human)
7	G (1)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
8	H, I (B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)

Sequence modifications

2: 1 - 218 (UniProt: Q6PMW3)

PDB	External Database	Details
Tyr 93	Ser 379	engineered mutation

3: 1 - 220 (UniProt: A0A1C6ZW60)

PDB	External Database	Details
Thr 168	Ala 471	conflict
Val 174	Ala 477	conflict

A: 1 - 594 (UniProt: P06756)

PDB	External Database	Details
-	Ala 60	deletion
-	Ser 61	deletion
Cys 400	Met 430	conflict
-	Gln 534	deletion
-	Lys 535	deletion

B: 5 - 539 (UniProt: P18564)

PDB	External Database	Details
Cys 249	Ile 287	conflict
Asn 517	His 469	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	196440.8
Non-Polymers*	Number of molecules	3
	Total formula weight	104.5
All*	Total formula weight	196545.2

*Water molecules are not included.