5NAF

Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	F-box-like/WD repeat-containing protein TBL1XR1	polymer	402	43904.7	4	UniProt (Q8BHJ5) Pfam (PF00400)	Mus musculus (Mouse)	Nuclear receptor corepressor/HDAC3 complex subunit TBLR1,TBL1-related protein 1,Transducin beta-like 1X-related protein 1
2	E, F (E, F)	Methyl-CpG-binding protein 2	polymer	25	2929.6	2	UniProt (Q9Z2D6)	Mus musculus	MeCp2
3	G, H, I, J, K... (A, B, C, D)	GLYCEROL	non-polymer		92.1	19	Chemie (GOL)
4	AA, BA, CA, DA, EA... (B, C, D, E, F...)	water	water		18.0	514	Chemie (HOH)

Sequence modifications

A, B, C, D: 134 - 514 (UniProt: Q8BHJ5)

PDB	External Database	Details
Met 113	-	initiating methionine
Gly 114	-	expression tag
Ser 115	-	expression tag
Ser 116	-	expression tag
His 117	-	expression tag
His 118	-	expression tag
His 119	-	expression tag
His 120	-	expression tag
His 121	-	expression tag
His 122	-	expression tag
Ser 123	-	expression tag
Ser 124	-	expression tag
Gly 125	-	expression tag
Leu 126	-	expression tag
Glu 127	-	expression tag
Val 128	-	expression tag
Leu 129	-	expression tag
Phe 130	-	expression tag
Gln 131	-	expression tag
Gly 132	-	expression tag
Pro 133	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	181478.0
Non-Polymers*	Number of molecules	19
	Total formula weight	1749.8
All*	Total formula weight	183227.8

*Water molecules are not included.