5N8V
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, D, F) | Peroxin 14 | polymer | 69 | 7883.1 | 4 | UniProt (Q8IEW2) Pfam (PF04695) | Trypanosoma brucei brucei | |
| 2 | E, K, O, S (A, B, D, F) | 1-(2-azanylethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide | non-polymer | 519.6 | 4 | Chemie (KZZ) | |||
| 3 | F, G, H, L, P... (A, B, D) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | I, M, R, T (A, B, D, F) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 4 | Chemie (BME) | |||
| 5 | J, N (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | U, V, W, X (A, B, D, F) | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A, B, D, F: 2 - 66 (UniProt: Q8IEW2)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Met 0 | - | expression tag |
| Trp 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 31532.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3038.4 | |
| All* | Total formula weight | 34570.7 |
