5N5L
Crystal structure of human Pim-1 kinase in complex with a consensuspeptide and [2-oxo-2-(1H-pyrrol-2-yl)ethyl] 5-bromo-1H-indole-3-carboxylate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase pim-1 | polymer | 313 | 35712.6 | 1 | UniProt (P11309) Pfam (PF00069) | Homo sapiens (Human) | |
| 2 | B (B) | Pimtide | polymer | 14 | 1592.8 | 1 | Homo sapiens | ||
| 3 | C (A) | 5-bromanyl-1~{H}-indole-3-carboxylic acid | non-polymer | 240.1 | 1 | Chemie (8NZ) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A: 1 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Gly 250 | Arg 250 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37305.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 332.1 | |
| All* | Total formula weight | 37637.6 |
