5N0C
Crystal structure of the tetanus neurotoxin in complex with GM1a
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tetanus toxin | polymer | 1335 | 152909.8 | 2 | UniProt (P04958) Pfam (PF01742) Pfam (PF07952) Pfam (PF07953) Pfam (PF07951) In PDB | Clostridium tetani | Tentoxylysin |
2 | C, D | beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | branched | 998.9 | 2 | In PDB GlyTouCan (G48558GR) | |||
3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
5 | water | water | 18.0 | 452 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 1315 (UniProt: P04958)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Ala 372 | Arg 372 | engineered mutation |
Phe 375 | Tyr 375 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 305819.7 | |
Branched | Number of molecules | 2 |
Total formula weight | 1997.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 236.9 | |
All* | Total formula weight | 308054.4 |