5N0C

Crystal structure of the tetanus neurotoxin in complex with GM1a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0008320	molecular_function	protein transmembrane transporter activity
A	0016787	molecular_function	hydrolase activity
A	0030666	cellular_component	endocytic vesicle membrane
A	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
A	0044079	biological_process	symbiont-mediated perturbation of host neurotransmitter secretion
A	0046872	molecular_function	metal ion binding
A	0071806	biological_process	protein transmembrane transport
A	0090729	molecular_function	toxin activity
A	0141157	biological_process	symbiont-mediated suppression of host exocytosis
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0008320	molecular_function	protein transmembrane transporter activity
B	0016787	molecular_function	hydrolase activity
B	0030666	cellular_component	endocytic vesicle membrane
B	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
B	0044079	biological_process	symbiont-mediated perturbation of host neurotransmitter secretion
B	0046872	molecular_function	metal ion binding
B	0071806	biological_process	protein transmembrane transport
B	0090729	molecular_function	toxin activity
B	0141157	biological_process	symbiont-mediated suppression of host exocytosis

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. LLMHELIHVL

Chain	Residue	Details
A	LEU230-LEU239

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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