5MZV
IL-23:IL-23R:Nb22E11 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-12 subunit beta | polymer | 328 | 37212.9 | 1 | UniProt (P29460) Pfam (PF10420) | Homo sapiens (Human) | IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2 |
| 2 | B (B) | Interleukin-23 subunit alpha | polymer | 198 | 21865.9 | 1 | UniProt (Q9NPF7) Pfam (PF16649) | Homo sapiens (Human) | IL-23-A,Interleukin-23 subunit p19,IL-23p19 |
| 3 | C (C) | Interleukin-23 receptor | polymer | 330 | 38377.6 | 1 | UniProt (Q5VWK5) | Homo sapiens (Human) | IL-23R |
| 4 | D (D) | Nanobody 22E11 | polymer | 156 | 16832.8 | 1 | Lama glama (llama) | ||
| 5 | E (E) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G07617FP) | |||
| 6 | F, H, I (F, H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G (G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 8 | J, L, M (A, C) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 9 | K (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 10 | N, O (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 11 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
B: 1 - 189 (UniProt: Q9NPF7)
C: 1 - 317 (UniProt: Q5VWK5)
| PDB | External Database | Details |
|---|---|---|
| Gly 190 | - | expression tag |
| Thr 191 | - | expression tag |
| Lys 192 | - | expression tag |
| His 193 | - | expression tag |
| His 194 | - | expression tag |
| His 195 | - | expression tag |
| His 196 | - | expression tag |
| His 197 | - | expression tag |
| His 198 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ile 318 | - | expression tag |
| Glu 319 | - | expression tag |
| Gly 320 | - | expression tag |
| Arg 321 | - | expression tag |
| Gly 322 | - | expression tag |
| Thr 323 | - | expression tag |
| Lys 324 | - | expression tag |
| His 325 | - | expression tag |
| His 326 | - | expression tag |
| His 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 114289.3 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 3094.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 571.8 | |
| All* | Total formula weight | 117955.9 |
