5MXD
BACE-1 IN COMPLEX WITH LIGAND 32397778
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Beta-secretase 1 | polymer | 432 | 48111.1 | 3 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
| 2 | A, B, C | ~{N},~{N}-dimethyl-2-pyrrolidin-1-yl-quinazolin-4-amine | non-polymer | 242.3 | 3 | Chemie (III) | |||
| 3 | A, B, C | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) |
Sequence modifications
A, B, C: -39 - 385 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Met -46 | - | initiating methionine |
| His -45 | - | expression tag |
| His -44 | - | expression tag |
| His -43 | - | expression tag |
| His -42 | - | expression tag |
| His -41 | - | expression tag |
| His -40 | - | expression tag |
| Thr -5 | Arg 56 | conflict |
| Thr -4 | Arg 57 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 144333.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 833.3 | |
| All* | Total formula weight | 145166.7 |
