5MWH
Crystal structure of the human BRPF1 bromodomain in complex with BZ089
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peregrin | polymer | 116 | 13703.7 | 2 | UniProt (P55201) Pfam (PF00439) | Homo sapiens (Human) | Bromodomain and PHD finger-containing protein 1,Protein Br140 |
| 2 | C, D (A, B) | ~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-4-(2-methylpropyl)benzenesulfonamide | non-polymer | 486.6 | 2 | Chemie (UWX) | |||
| 3 | E, F (B) | NITRATE ION | non-polymer | 62.0 | 2 | Chemie (NO3) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A, B: 626 - 740 (UniProt: P55201)
| PDB | External Database | Details |
|---|---|---|
| Ser 625 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27407.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1097.2 | |
| All* | Total formula weight | 28504.6 |
