5MQ1
Crystal structure of the BRD7 bromodomain in complex with BI-9564
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 7 | polymer | 112 | 13175.3 | 1 | UniProt (Q9NPI1) Pfam (PF00439) | Homo sapiens (Human) | 75 kDa bromodomain protein,Protein CELTIX-1 |
| 2 | B (A) | 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one | non-polymer | 353.4 | 1 | Chemie (5U6) | |||
| 3 | C, D (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | H (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | I, J, K, L, M... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 7 | T (A) | water | water | 18.0 | 224 | Chemie (HOH) |
Sequence modifications
A: 129 - 239 (UniProt: Q9NPI1)
| PDB | External Database | Details |
|---|---|---|
| Met 128 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13175.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1297.6 | |
| All* | Total formula weight | 14472.9 |
