5MLJ
Bromodomain of Human GCN5 with 4-bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone acetyltransferase KAT2A | polymer | 112 | 13287.3 | 2 | UniProt (Q92830) Pfam (PF00439) | Homo sapiens (Human) | General control of amino acid synthesis protein 5-like 2,Histone acetyltransferase GCN5,HsGCN5,Lysine acetyltransferase 2A,STAF97 |
| 2 | C, E (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 3 | D, F (A, B) | 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one | non-polymer | 377.3 | 2 | Chemie (9ST) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 366 | Chemie (HOH) |
Sequence modifications
A, B: 729 - 837 (UniProt: Q92830)
| PDB | External Database | Details |
|---|---|---|
| Ser 726 | - | expression tag |
| Met 727 | - | expression tag |
| Glu 728 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26574.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 878.7 | |
| All* | Total formula weight | 27453.3 |
