5MLJ

Bromodomain of Human GCN5 with 4-bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
B	0004402	molecular_function	histone acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue EDO A 901

Chain	Residue
A	GLN732
A	LEU733
A	THR736
A	ARG770
A	ARG790
A	LEU834
A	HOH1025
A	HOH1055

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site_id	AC2
Number of Residues	9
Details	binding site for residue 9ST A 902

Chain	Residue
A	PRO752
A	PHE753
A	PRO756
A	GLU761
A	TYR807
A	ASN808
A	TYR814
A	HOH1013
A	TRP751

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO B 901

Chain	Residue
A	ALA820
A	HOH1051
B	HOH1038
B	HOH1040

---

site_id	AC4
Number of Residues	9
Details	binding site for residue 9ST B 902

Chain	Residue
B	TRP751
B	PRO752
B	PHE753
B	PRO756
B	GLU761
B	TYR807
B	ASN808
B	TYR814
B	HOH1004

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. AwpFmepvKkseap..DYYevIrfpIdlktMterlrsry..Yvtrklfvadlqr.ViaNCreY

Chain	Residue	Details
A	ALA750-TYR807

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23142079","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 524

Chain

Residue

Details

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site_id	MCSA2
Number of Residues
Details	M-CSA 524

Chain

Residue

Details

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