5MKX
1.68A STRUCTURE PCAF BROMODOMAIN WITH 4-chloro-2-methyl-5-(methylamino)pyridazin-3(2H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone acetyltransferase KAT2B | polymer | 119 | 14172.4 | 2 | UniProt (Q92831) Pfam (PF00439) | Homo sapiens (Human) | Histone acetyltransferase PCAF,Histone acetylase PCAF,Lysine acetyltransferase 2B,P300/CBP-associated factor,P/CAF |
| 2 | C, F (A, B) | 4-chloranyl-2-methyl-5-(methylamino)pyridazin-3-one | non-polymer | 173.6 | 2 | Chemie (82I) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | E (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 5 | G (B) | 1,4-BUTANEDIOL | non-polymer | 90.1 | 1 | Chemie (BU1) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 360 | Chemie (HOH) |
Sequence modifications
A, B: 715 - 831 (UniProt: Q92831)
| PDB | External Database | Details |
|---|---|---|
| Ser 713 | - | expression tag |
| Met 714 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28344.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 771.7 | |
| All* | Total formula weight | 29116.4 |
