5MHM

FXIIIa in complex with the inhibitor ZED1630

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Coagulation factor XIII A chain	polymer	738	84206.0	2	UniProt (P00488) Pfam (PF00868) Pfam (PF01841) Pfam (PF00927) In PDB	Homo sapiens (human)	Coagulation factor XIIIa,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain
2	H, O	inhibitor ZED1630	polymer	8	935.2	2		synthetic construct
3	A, B	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
4	A, B	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
5	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6	A, B	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
7		water	water		18.0	841	Chemie (HOH)

Sequence modifications

A, B: 1 - 731 (UniProt: P00488)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ile 649	Thr 650	engineered mutation
Glu 651	Gln 652	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170282.4
Non-Polymers*	Number of molecules	19
	Total formula weight	1344.3
All*	Total formula weight	171626.7

*Water molecules are not included.