5MHM

FXIIIa in complex with the inhibitor ZED1630

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Coagulation factor XIII A chain	polymer	738	84206.0	2	UniProt (P00488) Pfam (PF00868) Pfam (PF01841) Pfam (PF00927)	Homo sapiens (human)	Coagulation factor XIIIa,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain
2	C, D (H, O)	inhibitor ZED1630	polymer	8	935.2	2		synthetic construct
3	E, F, G, O, P... (A, B)	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
4	H, I, J, K, Q... (A, B)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
5	L, W (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6	M, N, T, U, V (A, B)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
7	AA, X, Y, Z (O, A, B, H)	water	water		18.0	841	Chemie (HOH)

Sequence modifications

A, B: 1 - 731 (UniProt: P00488)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ile 649	Thr 650	engineered mutation
Glu 651	Gln 652	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170282.4
Non-Polymers*	Number of molecules	19
	Total formula weight	1344.3
All*	Total formula weight	171626.7

*Water molecules are not included.